TIMM8A/DDP anticorps (AA 31-97) (AbBy Fluor® 647)
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- Antigène Voir toutes TIMM8A/DDP (TIMM8A) Anticorps
- TIMM8A/DDP (TIMM8A) (Translocase of Inner Mitochondrial Membrane 8A (TIMM8A))
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Épitope
- AA 31-97
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Reactivité
- Humain
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp TIMM8A/DDP est conjugé à/à la AbBy Fluor® 647
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Application
- Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
- Homologie
- Human,Mouse,Rat,Cow,Sheep,Pig
- Purification
- Purified by Protein A.
- Immunogène
- KLH conjugated synthetic peptide derived from human TIMM8A
- Isotype
- IgG
- Top Product
- Discover our top product TIMM8A Anticorps primaire
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- Indications d'application
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IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200 - Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1 μg/μL
- Buffer
- Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
- Agent conservateur
- ProClin
- Précaution d'utilisation
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
- Stock
- -20 °C
- Stockage commentaire
- Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
- Date de péremption
- 12 months
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- Antigène
- TIMM8A/DDP (TIMM8A) (Translocase of Inner Mitochondrial Membrane 8A (TIMM8A))
- Autre désignation
- TIMM8A (TIMM8A Produits)
- Synonymes
- anticorps TIMM8A, anticorps ddp, anticorps tim8a, anticorps timm8a, anticorps DDP, anticorps DDP1, anticorps DFN1, anticorps MTS, anticorps TIM8, anticorps im:6896085, anticorps zgc:100916, anticorps Ddp1, anticorps Timm8a, anticorps DXHXS1274E, anticorps Fci-12, anticorps Tim8a, anticorps translocase of inner mitochondrial membrane 8 homolog A (yeast), anticorps translocase of inner mitochondrial membrane 8A, anticorps translocase of inner mitochondrial membrane 8 homolog A1 (yeast), anticorps translocase of inner mitochondrial membrane 8A1, anticorps TIMM8A, anticorps timm8a, anticorps Timm8a1
- Sujet
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Synonyms: DDP 1, DDP, DDP1, Deafness dystonia protein 1, Deafness/dystonia peptide, DFN 1, DFN1, MGC12262, Mitochondrial import inner membrane translocase subunit Tim8 A, MTS, TIM 8A, TIM8A, TIMM 8A, Translocase of inner mitochondrial membrane 8 homolog A, X linked deafness dystonia protein, TIM8A_HUMAN.
Background: The majority of mitochondrial-directed proteins are encoded by the nuclear genome and are transported to the mitochondria via regulated processes involving the mitochondrial Tom and Tim proteins (1). The mitochondrial Tim protein family is comprised of a large group of evolutionarily conserved proteins that are found in most eukaryotes (1,2). Import of nuclear-encoded precursor proteins into and across the mitochondrial inner membrane is mediated by two distinct complexes, the Tim23 complex and the Tim22 complex, which differ in their substrate specificity (1). Defects in Tim proteins are implicated in several neuro-degenerative diseases, suggesting important roles for Tim proteins in development and health (3,4). Tim8A and Tim8B, which map to human chromosomes Xq22.1 and 11q23.1-q23.2, respectively, are conserved proteins of the mitochondrial intermembrane space, which are organized in hetero-oligomeric complex with Tim13 (5,6,7). Tim8A is highly expressed in fetal and adult brain (5). Tim8A is mutated in deafness dystonia syndrome, a novel type of disease that causes severe neurological defects, thought to be caused by a defective mitochondrial protein transport system (5,8).
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