SPR anticorps (AA 101-200) (AbBy Fluor® 350)

N° du produit ABIN1393299

Détail du produit anti-SPR anticorps (AbBy Fluor® 350)

Antigène: SPR (Sepiapterin Reductase (SPR))

Épitope: AA 101-200

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp SPR est conjugé à/à la AbBy Fluor® 350

Application: Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Réactivité croisée: Humain, Souris, Rat

Homologie: Pig,Horse,Rabbit

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic peptide derived from human Sepiapterin reductase

Isotype: IgG

Information d'application

Indications d'application: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Date de péremption: 12 months

Détails sur SPR

Antigène: SPR (Sepiapterin Reductase (SPR))

Autre désignation: SPR/Sepiapterin reductase (SPR Produits)

Synonymes: anticorps SDR38C1, anticorps AA409688, anticorps ENSMUSG00000071345, anticorps Gm10328, anticorps CG12117, anticorps Dmel\\CG12117, anticorps SR, anticorps sptr, anticorps xspr, anticorps DDBDRAFT_0188686, anticorps DDBDRAFT_0191275, anticorps DDB_0188686, anticorps DDB_0191275, anticorps zgc:194446, anticorps sepiapterin reductase, anticorps Sepiapterin reductase, anticorps sepiapterin reductase L homeolog, anticorps sepiapterin reductase b, anticorps SPR, anticorps Spr, anticorps Sptr, anticorps spr.L, anticorps sprE, anticorps CpipJ_CPIJ000511, anticorps sr, anticorps spr, anticorps sprb

Sujet:

Synonyms: SDR38C1, Sepiapterin reductase 7,8 dihydrobiopterin:NADP+ oxidoreductase, Sepiapterin reductase, Short chain dehydrogenase/reductase family 38C, member 1, SPR, SPRE_HUMAN.

Background: SPR, also known as sepiapterin reductase, is a homodimeric cytoplasmic protein that belongs to the sepiapterin reductase family. SPR functions as an NADH-dependent aldo-keto reductase and specifically catalyzes the reduction of pteridine derivatives. In addition, SPR plays an important role in tetrahydrobiopterin (BH4) biosynthesis, catalyzing the final reduction step of the synthesis pathway. BH4 is an essential cofactor for the hydroxylation of the aromatic amino acids (tryptophan, tyrosine and phenylalanine) and is required for proper dopamine synthesis. Mutations in the gene encoding SPR can cause sepiapterin reductase deficiency, a monoamine neurotransmitter deficiency without hyperphenylalaninemia. Sepiapterin reductase deficiency interferes with BH4 synthesis, resulting in DOPA-responsive dystonia and a variety of other human diseases. In addition, SPR mRNA expression is increased in the brain of Parkinson?s Disease (PD) patients, suggesting that SPR may play a role in PD.

Pathways: Regulation of Systemic Arterial Blood Pressure by Hormones, Feeding Behaviour, Smooth Muscle Cell Migration