Ensa anticorps (AA 51-121) (Biotin)

N° du produit ABIN1393357

Détail du produit anti-Ensa anticorps (Biotin)

Antigène: Ensa (ENSA) (Endosulfine alpha (ENSA))

Épitope: AA 51-121

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Ensa est conjugé à/à la Biotin

Application: ELISA, Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Homologie: Human,Mouse,Rat,Dog,Cow,Horse,Rabbit

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic peptide derived from human ENSA/ARPP-19

Isotype: IgG

Information d'application

Indications d'application: WB 1:300-5000
IHC-P 1:200-400
IHC-F 1:100-500

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C for 12 months.

Date de péremption: 12 months

Détails sur Ensa

Antigène: Ensa (ENSA) (Endosulfine alpha (ENSA))

Autre désignation: ENSA/ARPP-19 (ENSA Produits)

Synonymes: anticorps ARPP-19e, anticorps 1700020C18Rik, anticorps 2610007F17Rik, anticorps AI451924, anticorps ensa, anticorps si:dkeyp-24a7.3, anticorps ensaa, anticorps endosulfine alpha, anticorps endosulfine alpha a, anticorps endosulfine alpha S homeolog, anticorps ENSA, anticorps Ensa, anticorps ensa, anticorps ensaa, anticorps ensa.S

Sujet:

Synonyms: Alpha endosulfine, ARPP 19e, Endosulfine alpha, ENSA_HUMAN.

Background: Sulfonylureas are a class of drugs commonly used in the management of noninsulin-dependent diabetes mellitus. ENSA/ARPP-19, also known as ARPP-19e, is a 121 amino acid protein that localizes to the cytoplasm and belongs to the endosulfine family. ENSA/ARPP-19 is an endogenous regulator of the _-cell K(ATP) channels and reduces K(ATP) channel currents by inhibiting sulfonylurea from binding to the receptor thereby stimulating insulin secretion by pancreatic _ cells. It is suggested that ENSA/ARPP-19 expression is decreased in brains of both Alzheimer's disease (AD) and Down's syndrome patients. Widely expressed with high levels in skeletal muscle and brain and lower levels in pancreas, ENSA/ARPP-19 is phosphorylated by PKA and exists as eight alternatively spliced isoforms. ENSA/ARPP-19 is encoded by a gene located on human chromosome 1q21.3.