CBLN2 anticorps (AA 151-224) (Biotin)

N° du produit ABIN1393489

Détail du produit anti-CBLN2 anticorps (Biotin)

Antigène: CBLN2 (Cerebellin 2 Precursor (CBLN2))

Épitope: AA 151-224

Reactivité: Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp CBLN2 est conjugé à/à la Biotin

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Réactivité croisée: Rat

Homologie: Human,Mouse,Dog,Cow,Pig,Horse,Rabbit

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic peptide derived from human CBLN2

Isotype: IgG

Information d'application

Indications d'application: WB 1:300-5000
IHC-P 1:200-400
IHC-F 1:100-500

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C for 12 months.

Date de péremption: 12 months

Détails sur CBLN2

Antigène: CBLN2 (Cerebellin 2 Precursor (CBLN2))

Autre désignation: CBLN2 (CBLN2 Produits)

Synonymes: anticorps MGC64397, anticorps si:dkey-82k12.11, anticorps 6330593N19Rik, anticorps A730004O05, anticorps zgc:163051, anticorps cerebellin 2 precursor, anticorps cerebellin 2 precursor L homeolog, anticorps cerebellin 2a precursor, anticorps cerebellin 2 precursor protein, anticorps cerebellin 2b precursor, anticorps CBLN2, anticorps cbln2.L, anticorps cbln2, anticorps cbln2a, anticorps Cbln2, anticorps cbln2b

Sujet:

Synonyms: A730004O05, Cbln2, CBLN2_HUMAN, Cerebellin 2, Cerebellin 2 precursor, Cerebellin-2, OTTHUMP00000163726.

Background: Cerebellin (CER), which was originally isolated from rat cerebellum, is a hexadecapeptide derived from a larger precursor Cerebellin 1, also designated precerebellin 1 or Cbln1. Four propeptides, Cerebellin 1, Cerebellin 2 (Cbln2), Cerebellin 3 (Cbln3), and Cerebellin 4 (Cbln4), comprise the precerebellin subfamily within the C1q protein family. Cerebellin family members act as transneuronal regulators of synapse development and synaptic plasticity in various brain regions. CER and it metabolite des-Ser1-cerebellin are also expressed in several extra-cerebellar tissues, including adrenal gland. Cerebellin 1, 2 and 3 assemble into homomeric and heteromeric complexes, thereby influencing each other?s degradation and secretion. Cerebellin 3 is not able to form homomeric complexes, and can only be secreted upon forming a heteromeric complex with Cerebellin 1. Decreased concentrations of CER has been found in the brain of patients with olivopontocerebellar atrophy (OPCA) and Shy-Drager syndrome, suggesting a role for CER in the pathology of these diseases.