Glutathione Synthetase anticorps (AA 81-160) (Biotin)
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- Antigène Voir toutes Glutathione Synthetase (GSS) Anticorps
- Glutathione Synthetase (GSS)
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Épitope
- AA 81-160
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Reactivité
- Humain, Souris, Rat
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp Glutathione Synthetase est conjugé à/à la Biotin
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Application
- Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
- Réactivité croisée
- Humain, Souris, Rat
- Homologie
- Dog,Cow,Sheep,Pig,Horse
- Purification
- Purified by Protein A.
- Immunogène
- KLH conjugated synthetic peptide derived from human Glutathione Syntase
- Isotype
- IgG
- Top Product
- Discover our top product GSS Anticorps primaire
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- Indications d'application
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WB 1:300-5000
IHC-P 1:200-400 - Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1 μg/μL
- Buffer
- Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
- Agent conservateur
- ProClin
- Précaution d'utilisation
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
- Stock
- -20 °C
- Stockage commentaire
- Store at -20°C for 12 months.
- Date de péremption
- 12 months
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- Antigène
- Glutathione Synthetase (GSS)
- Autre désignation
- GSS/Glutathione Synthetase (GSS Produits)
- Synonymes
- anticorps PRNP, anticorps 6835, anticorps CG32497, anticorps CG33065, anticorps CG6835, anticorps Dmel\\CG6835, anticorps F21A20.90, anticorps F21A20_90, anticorps GLUTATHIONE SYNTHETASE, anticorps GSHB, anticorps glutathione synthetase 2, anticorps GSHS, anticorps AI314904, anticorps GS-A/GS-B, anticorps gssls-a, anticorps glutathione synthetase, anticorps Glutathione Synthetase, anticorps glutathione synthetase 2, anticorps glutathione synthetase L homeolog, anticorps GSS, anticorps GSH2, anticorps Tola_1250, anticorps PC1_3711, anticorps Dd586_3633, anticorps Kvar_0701, anticorps Alvin_0197, anticorps Nhal_0215, anticorps BC1002_0254, anticorps Cseg_4017, anticorps Snov_3844, anticorps Aazo_1904, anticorps M301_2613, anticorps Bresu_0515, anticorps Isop_1460, anticorps Marme_4020, anticorps Thicy_0325, anticorps Sinme_3668, anticorps Mesop_0757, anticorps Gss, anticorps gss.L
- Sujet
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Synonyms: Glutathione synthase; GSH S; GSH synthetase; GSH-S; GSHB_HUMAN; GSHS; GSS antibodyMGC14098; OTTHUMP00000030711.
Background: GSS (Glutathione synthetase) is a 474 amino acid protein encoded by the gene located at human chromosome 20q11.2. GSS consists of three loops projecting from an antiparallel -sheet, a parallel -sheet and a lid of anti-parallel sheets, which provide access to the ATP-binding site. Although Southern blot and gene analysis suggest that GSS may be the only member of a unique family, the crystal structure indicates that GSS belongs to the ATP-GRASP superfamily. GSS is expressed in hemocytes and nucleated cells, including the brain. GSS occurs as a homodimer. There are two steps in the production of Glutathione, begining with GSS (Glutathione synthetase) is a 474 amino acid protein encoded by the gene located at human chromosome 20q11.2. GSS consists of three loops projecting from an antiparallel -sheet, a parallel -sheet and a lid of anti-parallel sheets, which provide access to the ATP-binding site. Although Southern blot and gene analysis suggest that GSS may be the only member of a unique family, the crystal structure indicates that GSS belongs to the ATP-GRASP superfamily. GSS is expressed in hemocytes and nucleated cells, including the brain. GSS occurs as a homodimer. There are two steps in the production of Glutathione, begining with ©-GCS and ending with GSS. In an ATP-dependent reaction, GSS produces Glutathione from ©-glutamylcysteine and glycine precursors. Partial hepatectomy, diethyl maleate, buthionine sulfoximine, tert-butylhaydroquinone and thioacetamide increase the ex-pression of GSS, which causes an increase in Glutathione levels. An inherited autosomal recessive disorder, 5-oxoprolinuria (pyroglutamic aciduria), is caused by GSS deficiencies, which leads to central nervous system damage, hemolytic anemia, metabolic acidosis and urinary excretion of 5-oxoproline. A missense mutation in the gene encoding GSS leads to a GSS deficiency restricted to erythrocytes, which causes only hemolytic anemia.-GCS and ending with GSS.
- Pathways
- L'effet Warburg
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