JARID2 anticorps (AA 301-400) (AbBy Fluor® 350)
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- Antigène Voir toutes JARID2 Anticorps
- JARID2 (Jumonji, AT Rich Interactive Domain 2 (JARID2))
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Épitope
- AA 301-400
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Reactivité
- Humain, Rat
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp JARID2 est conjugé à/à la AbBy Fluor® 350
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Application
- Western Blotting (WB), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunofluorescence (Cultured Cells) (IF (cc))
- Réactivité croisée
- Humain, Rat
- Homologie
- Mouse,Dog,Cow,Sheep,Pig,Horse,Chicken
- Purification
- Purified by Protein A.
- Immunogène
- KLH conjugated synthetic peptide derived from human Jarid2/Jumonji
- Isotype
- IgG
- Top Product
- Discover our top product JARID2 Anticorps primaire
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- Indications d'application
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IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200 - Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1 μg/μL
- Buffer
- Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
- Agent conservateur
- ProClin
- Précaution d'utilisation
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
- Stock
- -20 °C
- Stockage commentaire
- Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
- Date de péremption
- 12 months
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- Antigène
- JARID2 (Jumonji, AT Rich Interactive Domain 2 (JARID2))
- Autre désignation
- Jarid2/Jumonji (JARID2 Produits)
- Synonymes
- anticorps JMJ, anticorps Jmj, anticorps jumonji, anticorps JARID2, anticorps jarid2, anticorps jmj, anticorps si:dkey-211c3.1, anticorps Jumonji, anticorps jarid2-a, anticorps jarid2-b, anticorps jarid2.S, anticorps jarid2b, anticorps jumonji and AT-rich interaction domain containing 2, anticorps jumonji, AT rich interactive domain 2, anticorps jumonji, AT rich interactive domain 2a, anticorps jumonji, AT rich interactive domain 2b, anticorps jumonji and AT-rich interaction domain containing 2 L homeolog, anticorps JARID2, anticorps Jarid2, anticorps jarid2a, anticorps jarid2, anticorps jarid2b, anticorps jarid2.L
- Sujet
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Synonyms: JMJ, Protein Jumonji, Jumonji/ARID domain-containing protein 2, JARID2
Background: Regulator of histone methyltransferase complexes that plays an essential role in embryonic development, including heart and liver development, neural tube fusion process and hematopoiesis. Acts by modulating histone methyltransferase activity and promoting the recruitment of histone methyltransferase complexes to their target genes. Binds DNA and mediates the recruitment of the PRC2 complex to target genes in embryonic stem cells. Does not have histone demethylase activity but regulates activity of various histone methyltransferase complexes. In embryonic stem cells, it associates with the PRC2 complex and inhibits trimethylation of 'Lys-27' of histone H3 (H3K27me3) by the PRC2 complex, thereby playing a key role in differentiation of embryonic stem cells and normal development. In cardiac cells, it is required to repress expression of cyclin-D1 (CCND1) by activating methylation of 'Lys-9' of histone H3 (H3K9me) by the GLP1/EHMT1 and G9a/EHMT2 histone methyltransferases. Also acts as a transcriptional repressor of ANF via its interaction with GATA4 and NKX2-5. Participates in the negative regulation of cell proliferation signaling.
- ID gène
- 3720
- UniProt
- Q92833
- Pathways
- Chromatin Binding
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