KALRN anticorps (AA 1401-1500) (Biotin)

N° du produit ABIN1393759

Détail du produit anti-KALRN anticorps (Biotin)

Antigène: KALRN (Kalirin, RhoGEF Kinase (KALRN))

Épitope: AA 1401-1500

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp KALRN est conjugé à/à la Biotin

Application: ELISA, Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Homologie: Human,Mouse,Rat,Dog,Pig,Horse,Chicken

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic peptide derived from human KALRN/Duo

Isotype: IgG

Information d'application

Indications d'application: IHC-P 1:200-400
IHC-F 1:100-500

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C for 12 months.

Date de péremption: 12 months

Détails sur KALRN

Antigène: KALRN (Kalirin, RhoGEF Kinase (KALRN))

Autre désignation: KALRN/Duo (KALRN Produits)

Synonymes: anticorps ARHGEF24, anticorps CHD5, anticorps CHDS5, anticorps DUET, anticorps DUO, anticorps HAPIP, anticorps TRAD, anticorps KALRN, anticorps 2210407G14Rik, anticorps AV235988, anticorps E530005C20Rik, anticorps Gm539, anticorps Hapip, anticorps Duo, anticorps Kalirin, anticorps kalirin RhoGEF kinase, anticorps kalirin, RhoGEF kinase, anticorps kalirin, anticorps kalirin RhoGEF kinase L homeolog, anticorps putative kalirin, anticorps KALRN, anticorps LOC460643, anticorps Kalrn, anticorps kalrn, anticorps kalrn.L, anticorps LOC100473997, anticorps Smp_162970

Sujet:

Synonyms: Duo, FLJ16443, HAPIP, Huntingtin associated protein interacting protein duo , Huntingtin-associated protein-interacting protein, Kalirin isoform 2, Kalirin, KALRN , KALRN_HUMAN , Protein Duo, RhoGEF kinase, Serine/threonine kinase with Dbl and pleckstrin homology domains , Serine/threonine-protein kinase with Dbl- and pleckstrin homology domain, TRAD.

Background: HAP1 (huntingtin-associated protein 1) binds to huntingtin (1). Huntingtin is a protein that contains a polyglutamine region and when the number of glutamine repeats exceeds 35, the gene encodes a version of huntingtin that leads to Huntington?s disease (HD) (2,3). The ability of HAP1 to bind to huntingtin is enhanced by an expanded polyglutamine repeat region (1). HAP1 shows neuronal localization and moves with huntingtin in nerve fibers (4,5). HAP1 is primarily expressed in brain tissue, with greater expression in the olfactory bulb and brain stem (1). Mouse HAP1 is localized to membrane-bound organelles including large endosomes, tubulovesicular structures and budding vesicles in neurons (6). Duo, also designated huntingtin-associated protein interacting protein or HAPIP, binds Huntingtin-associated protein 1 (HAP1) and may have a role in vesicle trafficking and cytoskeletal function.

Pathways: Neurotrophin Signaling Pathway