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NOTUM anticorps (AA 351-450) (AbBy Fluor® 488)

NOTUM Reactivité: Humain WB, IF (cc), IF (p) Hôte: Lapin Polyclonal AbBy Fluor® 488
N° du produit ABIN1394014
  • Antigène Voir toutes NOTUM Anticorps
    NOTUM (Notum Pectinacetylesterase Homolog (NOTUM))
    Épitope
    • 14
    • 8
    • 7
    • 6
    • 6
    • 2
    • 1
    • 1
    AA 351-450
    Reactivité
    • 37
    • 3
    • 2
    Humain
    Hôte
    • 37
    Lapin
    Clonalité
    • 37
    Polyclonal
    Conjugué
    • 10
    • 5
    • 4
    • 4
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp NOTUM est conjugé à/à la AbBy Fluor® 488
    Application
    • 33
    • 21
    • 12
    • 12
    • 5
    • 3
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
    Homologie
    Human,Mouse,Rat,Dog,Cow,Horse
    Purification
    Purified by Protein A.
    Immunogène
    KLH conjugated synthetic peptide derived from human NOTUM
    Isotype
    IgG
    Top Product
    Discover our top product NOTUM Anticorps primaire
  • Indications d'application
    IF(IHC-P) 1:50-200
    IF(IHC-F) 1:50-200
    IF(ICC) 1:50-200
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 μg/μL
    Buffer
    Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
    Agent conservateur
    ProClin
    Précaution d'utilisation
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Stock
    -20 °C
    Stockage commentaire
    Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
    Date de péremption
    12 months
  • Antigène
    NOTUM (Notum Pectinacetylesterase Homolog (NOTUM))
    Autre désignation
    NOTUM (NOTUM Produits)
    Synonymes
    anticorps 5730593N15Rik, anticorps RGD1307119, anticorps notum, palmitoleoyl-protein carboxylesterase, anticorps notum pectinacetylesterase homolog (Drosophila), anticorps NOTUM, palmitoleoyl-protein carboxylesterase, anticorps NOTUM, anticorps Notum
    Sujet

    Synonyms: NOTUM, notum pectinacetylesterase homolog Drosophila, Notum pectinacetylesterase homolog, NOTUM_HUMAN.

    Background: Notum is a 496 amino acid secreted protein that belongs to the pectinacetylesterase family and may deacetylate GlcNAc residues on cell surface glycans. The gene that encodes Notum consists of approximately 9,334 bases and maps to human chromosome 17q25.3. Encoding more than 1,200 genes, chromosome 17 comprises over 2.5 % of the human genome. Two key tumor suppressor genes are associated with chromosome 17, namely, p53 and BRCA1. Tumor suppressor p53 is necessary for maintenance of cellular genetic integrity by moderating cell fate through DNA repair versus cell death. Malfunction or loss of p53 expression is associated with malignant cell growth and Li-Fraumeni syndrome. Like p53, BRCA1 is directly involved in DNA repair, though specifically it is recognized as a genetic determinant of early onset breast cancer and predisposition to cancers of ovary, colon, prostate gland and fallopian tubes.

    ID gène
    147111
    UniProt
    Q6P988
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