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PHYHIP anticorps (AA 231-330) (Biotin)

PHYHIP Reactivité: Humain WB, ELISA, IHC (p), IHC (fro) Hôte: Lapin Polyclonal Biotin
N° du produit ABIN1394137
  • Antigène Voir toutes PHYHIP Anticorps
    PHYHIP (Phytanoyl-CoA 2-Hydroxylase Interacting Protein (PHYHIP))
    Épitope
    • 14
    • 4
    • 1
    • 1
    AA 231-330
    Reactivité
    • 23
    • 8
    • 8
    • 7
    • 5
    • 4
    • 4
    • 4
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    Humain
    Hôte
    • 23
    Lapin
    Clonalité
    • 23
    Polyclonal
    Conjugué
    • 10
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp PHYHIP est conjugé à/à la Biotin
    Application
    • 23
    • 13
    • 13
    • 4
    • 3
    • 2
    • 1
    Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))
    Homologie
    Human,Mouse,Rat,Dog,Cow,Pig,Horse,Rabbit
    Purification
    Purified by Protein A.
    Immunogène
    KLH conjugated synthetic peptide derived from human PHYHIP
    Isotype
    IgG
    Top Product
    Discover our top product PHYHIP Anticorps primaire
  • Indications d'application
    WB 1:300-5000
    IHC-P 1:200-400
    IHC-F 1:100-500
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 μg/μL
    Buffer
    Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
    Agent conservateur
    ProClin
    Précaution d'utilisation
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Stock
    -20 °C
    Stockage commentaire
    Store at -20°C for 12 months.
    Date de péremption
    12 months
  • Antigène
    PHYHIP (Phytanoyl-CoA 2-Hydroxylase Interacting Protein (PHYHIP))
    Autre désignation
    PHYHIP (PHYHIP Produits)
    Synonymes
    anticorps PHYHIP, anticorps DYRK1AP3, anticorps PAHX-AP, anticorps PAHXAP1, anticorps AW049870, anticorps C630010D02Rik, anticorps Lnap1ip, anticorps PAHX-AP1, anticorps phytanoyl-CoA 2-hydroxylase interacting protein, anticorps phytanoyl-CoA hydroxylase interacting protein, anticorps PHYHIP, anticorps phyhip, anticorps Phyhip
    Sujet

    Synonyms: DYRK1A interacting protein 3, DYRK1AP3, PAHX AP1, PAHXAP1, phytanoyl CoA 2 hydroxylase interacting protein, phytanoyl CoA alpha hydroxylase associated protein, Phytanoyl CoA hydroxylase associated protein 1, Phytanoyl CoA hydroxylase interacting protein, Similar to a putative C.elegans gene encoded in cosmid M01B2, PHYIP_HUMAN.

    Background: PHYHIP (Phytanoyl-CoA hydroxylase-interacting protein) is a 330 amino acid protein that is strongly expressed in brain, with weak expression in ovary, small intestine and ovary. In transgenic mice, overexpression of PHYHIP in heart results in tachycardia and tachyarrhythmia. PHYHIP interacts with the Refsum disease gene product, PAHX, indicating that PHYHIP may play a role in the CNS deficits of Refsum disease, which is characterized by cerebellar degeneration, neurologic damage and peripheral neuropathies. PHYHIP also interacts with Dyrk1A, a protein that that is overexpressed in brain of Down-syndrome patients, therefore PHYHIP may participate in some of the neurological abnormalities of Down syndrome. Significantly, the gene encoding PHYHIP is localized to a region of the short arm of human chromosome 8 that is frequently found deleted in prostate, breast and several other types of cancers.

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