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SIM2 anticorps (AA 321-430) (AbBy Fluor® 555)

SIM2 Reactivité: Humain IF (cc), IF (p) Hôte: Lapin Polyclonal AbBy Fluor® 555
N° du produit ABIN1394279
  • Antigène Voir toutes SIM2 Anticorps
    SIM2 (Single-Minded Homolog 2 (SIM2))
    Épitope
    • 14
    • 5
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 321-430
    Reactivité
    • 29
    • 5
    • 4
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Humain
    Hôte
    • 26
    • 3
    • 1
    Lapin
    Clonalité
    • 28
    • 2
    Polyclonal
    Conjugué
    • 13
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp SIM2 est conjugé à/à la AbBy Fluor® 555
    Application
    • 13
    • 12
    • 12
    • 11
    • 4
    • 3
    • 3
    • 1
    • 1
    Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
    Homologie
    Human,Mouse,Rat,Dog,Cow,Sheep,Pig,Horse
    Purification
    Purified by Protein A.
    Immunogène
    KLH conjugated synthetic peptide derived from human SIM2
    Isotype
    IgG
    Top Product
    Discover our top product SIM2 Anticorps primaire
  • Indications d'application
    IF(IHC-P) 1:50-200
    IF(IHC-F) 1:50-200
    IF(ICC) 1:50-200
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 μg/μL
    Buffer
    Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
    Agent conservateur
    ProClin
    Précaution d'utilisation
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Stock
    -20 °C
    Stockage commentaire
    Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
    Date de péremption
    12 months
  • Antigène
    SIM2 (Single-Minded Homolog 2 (SIM2))
    Autre désignation
    SIM2 (SIM2 Produits)
    Synonymes
    anticorps Xsim2, anticorps sim2-A, anticorps xSim, anticorps HMC13F06, anticorps HMC29C01, anticorps SIM, anticorps bHLHe15, anticorps single-minded family bHLH transcription factor 2 S homeolog, anticorps single-minded family bHLH transcription factor 2, anticorps single-minded homolog 2 (Drosophila), anticorps sim2.S, anticorps sim2, anticorps SIM2, anticorps Sim2
    Sujet

    Synonyms: bHLHe15, Class E basic helix loop helix protein 15, Class E basic helix-loop-helix protein 15, MGC119447, SIM 2, SIM, Sim2, SIM2_HUMAN, Single minded homolog 2 Drosophila, Single minded homolog 2, Single-minded homolog 2, Transcription factor SIM2.

    Background: The Per-Arnt-Sim (PAS) domain was identified as a 270 amino acid motif that mediates associations between various PAS family transcription factors. Several PAS domain family members have been identified including AhR, Arnt 1, and single-minded proteins (SIM1 and SIM2). The aromatic (aryl) hydrocarbon receptor, AhR, is a ligand dependent transcription factor that interacts with specific DNA sequences termed xenobiotic responsive elements (XREs) to activate several genes including CYP1A1, glutathione S-transferase Ya subunit and DT-diaphorase. The Ah receptor nuclear translocator protein 1 (Arnt 1) is required for ligand- dependent nuclear translocation of the Ah receptor and is also necessary for Ah receptor binding to the XRE element. Both SIM1 and SIM2 inhibit AhR/Arnt dimerization, thus inhibiting transcriptional activation. The SIM genes are thought to be involved in the directing and regionalization of tissues during development and the SIM2 gene, which is located on chromosome 21, is a candidate for the gene responsible for Down syndrome.

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