SLITRK2 anticorps (AA 311-410) (Biotin)

N° du produit ABIN1394305

Détail du produit anti-SLITRK2 anticorps (Biotin)

Antigène: SLITRK2 (SLIT and NTRK-Like Family, Member 2 (SLITRK2))

Épitope: AA 311-410

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp SLITRK2 est conjugé à/à la Biotin

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Homologie: Human,Mouse,Rat,Dog,Cow,Sheep,Pig,Horse,Rabbit,Guinea Pig

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic peptide derived from human SLITRK2

Isotype: IgG

Information d'application

Indications d'application: WB 1:300-5000
IHC-P 1:200-400
IHC-F 1:100-500

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C for 12 months.

Date de péremption: 12 months

Détails sur SLITRK2

Antigène: SLITRK2 (SLIT and NTRK-Like Family, Member 2 (SLITRK2))

Autre désignation: SLITRK2 (SLITRK2 Produits)

Synonymes: anticorps slitrk2, anticorps CXorf2, anticorps SLITL1, anticorps A930040J07, anticorps RGD1561361, anticorps SLIT and NTRK-like family, member 2, anticorps SLIT and NTRK like family member 2, anticorps SLITRK2, anticorps slitrk2, anticorps Slitrk2

Sujet:

Synonyms: CXorf2, KIAA1854, SLIK2_HUMAN, SLIT and NTRK like protein 2, SLIT and NTRK-like protein 2, SLITL1, SLITRK 2, Slitrk2.

Background: SLITRK family proteins are integral membrane proteins that have a C-terminal domain that is partially similar to TRK neurotrophin receptor proteins and two leucine-rich repeat (LRR) domains that are similar to those of SLIT proteins. SLITRK2 (SLIT and NTRK-like protein 2) is a 845 amino acid single-pass type I membrane protein that contains 14 LRR (leucine-rich) repeats and is expressed in neural tissues, with highest levels found in adult cerebral cortex. Overexpression of SLITRK2 leads to inhibition of unipolar neurites in cultured cells, suggesting that it suppresses neurite outgrowth. Inhibitory activity of SLITRK2 is localized to its C-terminal intracellular domain and without this region the protein induces neurite outgrowth. Variants in the gene encoding SLITRK2 may contribute to the development of bipolar disorder, autism spectrum disorder and schizophrenia. There are two isoforms of SLITRK2 that are produced as a result of alternative splicing events.