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NUMBL anticorps (AA 75-120) (AbBy Fluor® 350)

NUMBL Reactivité: Humain WB, IF (cc), IF (p) Hôte: Lapin Polyclonal AbBy Fluor® 350
N° du produit ABIN1394415
  • Antigène Voir toutes NUMBL Anticorps
    NUMBL (Numb Homolog (Drosophila)-Like (NUMBL))
    Épitope
    • 14
    • 9
    • 7
    • 5
    • 4
    • 2
    • 1
    • 1
    AA 75-120
    Reactivité
    • 46
    • 9
    • 9
    • 1
    Humain
    Hôte
    • 44
    • 1
    • 1
    Lapin
    Clonalité
    • 45
    • 1
    Polyclonal
    Conjugué
    • 12
    • 5
    • 5
    • 4
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp NUMBL est conjugé à/à la AbBy Fluor® 350
    Application
    • 31
    • 22
    • 16
    • 12
    • 12
    • 5
    • 4
    • 3
    • 3
    • 2
    Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
    Homologie
    Human,Mouse,Rat,Dog,Cow,Sheep,Horse,Rabbit
    Purification
    Purified by Protein A.
    Immunogène
    KLH conjugated synthetic peptide derived from human NUMBL
    Isotype
    IgG
    Top Product
    Discover our top product NUMBL Anticorps primaire
  • Indications d'application
    IF(IHC-P) 1:50-200
    IF(IHC-F) 1:50-200
    IF(ICC) 1:50-200
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 μg/μL
    Buffer
    Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
    Agent conservateur
    ProClin
    Précaution d'utilisation
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Stock
    -20 °C
    Stockage commentaire
    Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
    Date de péremption
    12 months
  • Antigène
    NUMBL (Numb Homolog (Drosophila)-Like (NUMBL))
    Autre désignation
    NUMBL (NUMBL Produits)
    Synonymes
    anticorps nbl, anticorps numb, anticorps cag3a, anticorps ctg3a, anticorps numbr, anticorps numb-r, anticorps tnrc23, anticorps numblike, anticorps CAG3A, anticorps CTG3a, anticorps NBL, anticorps NUMB-R, anticorps NUMBLIKE, anticorps NUMBR, anticorps TNRC23, anticorps NUMB like, endocytic adaptor protein, anticorps numb homolog-like L homeolog, anticorps NUMB-like, endocytic adaptor protein, anticorps numb-like, anticorps NUMBL, anticorps numbl.L, anticorps Numbl
    Sujet

    Synonyms: CAG 3A, CAG3A, CTG 3a, CTG3a, NBL, NUMB Drosophilia Homolog Like, Numb homolog Drosophila like, Numb homolog like, Numb like protein, NUMB R, Numb-like protein, Numb-R, Numb-related protein, NUMBL, NUMBL_HUMAN, NUMBR, TNRC 23, TNRC23.

    Background: In Drosophila, neuronal cell fate decisions are directed by NUMB, a signaling adapter protein with two protein-protein interaction domains, namely a phosphotyrosine-binding domain and a proline-rich SH3-binding region (PRR). The mammalian NUMB homolog plays a role in the determination of cell fate during development and binds with a variety of proteins, including Eps15, LNX1 and Notch 1. NumbL (NUMB-like protein), also known as Numb-R, NBL, CAG3A, CTG3a, NUMBLIKE or TNRC23, is a 609 amino acid cytoplasmic protein that, like NUMB, is thought to play a role in cell fate. Expressed at high levels in developing brain tissue, NumbL contains one PID (phosphotyrosine interaction domain) and plays an important role in neuronal differentiation, possibly associating with Eps15 and Notch 1. In mice, deletion of the NumbL gene is associated with early embryonic death, suggesting an essential role for NumbL in early development.

    Pathways
    Cell-Cell Junction Organization
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