GARP anticorps (AA 856-960) (Biotin)

N° du produit ABIN1395121

Détail du produit anti-GARP anticorps (Biotin)

Antigène: GARP (CNGB1) (Cyclic Nucleotide Gated Channel beta 1 (CNGB1))

Épitope: AA 856-960

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp GARP est conjugé à/à la Biotin

Application: ELISA, Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Homologie: Human,Mouse,Rat,Cow,Sheep,Pig,Horse,Rabbit

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic peptide derived from human CNGB1

Isotype: IgG

Information d'application

Indications d'application: IHC-P 1:200-400
IHC-F 1:100-500

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C for 12 months.

Date de péremption: 12 months

Détails sur GARP

Antigène: GARP (CNGB1) (Cyclic Nucleotide Gated Channel beta 1 (CNGB1))

Autre désignation: CNG4/GARP (CNGB1 Produits)

Synonymes: anticorps CNCG2, anticorps CNCG3L, anticorps CNCG4, anticorps CNG4, anticorps CNGB1B, anticorps GAR1, anticorps GARP, anticorps RCNC2, anticorps RCNCb, anticorps RCNCbeta, anticorps RP45, anticorps Gm1959, anticorps Cngb1b, anticorps CNGB1, anticorps si:ch211-160j6.1, anticorps cyclic nucleotide gated channel beta 1, anticorps cyclic nucleotide gated channel beta 1a, anticorps CNGB1, anticorps Cngb1, anticorps cngb1a

Sujet:

Synonyms: CNCG2, CNCG3L, CNCG4, CNG 4, CNG-4, CNG channel 4, CNG channel beta 1, CNG4, CNGB 1, CNGB1, CNGB1B, Cyclic nucleotide gated cation channel 4, Cyclic nucleotide gated cation channel, Cyclic nucleotide gated cation channel beta 1, Cyclic nucleotide gated cation channel gamma, Cyclic nucleotide gated cation channel modulatory subunit, Cyclic nucleotide gated channel photoreceptor cGMP gated 3 gamma like, Cyclic nucleotide gated channel beta 1, GAR1, Glutamic acid rich protein, RCNC2, RCNCb, RCNCbeta, RP45, CNGB1_HUMAN.

Background: Cyclic nucleotide-gated (CNG) cation channels are heteromeric complexes made up of principal alpha and modulatory beta subunits (1,2). The alpha subunits consist of CNG1-3 and form functional cation channels by themselves (1,2). The beta subunits consist of CNG4-6 and, unlike the alpha subunits, do not form functional channels, but rather modify the properties of channels (1,2). CNG channels are essential components of olfactory and visual transduction (1,2). In olfactory neurons, CNG2, CNG4.3 and CNG5 form Ca2+ permeable channels, which open and depolarize the cell in response to cAMP (1-3). In rod photoreceptors, CNG1 and CNG4.1 combine to form Ca ion permeable channels, which give rise to a current in response to cGMP (1-3). CNG3 and CNG6 are expressed in cone receptors and may combine to form a native cGMP-activated channel (2,3). CNG channels have been implicated in other areas (4-6). CNG1 is also expressed in medium-sized and small-sized arteries, suggesting a role for CNG in the regulation of arterial blood pressure and of blood supply to different regions (4). CNG1, CNG4.1 and CNG4.2 have been detected in the rat pineal gland (5). CNG2, CNG4.3 and CNG5 are present in GT1 cell lines and may play a role in the secretion of gonadotropin-releasing hormone (6).

UniProt: Q14028

Pathways: Regulation of G-Protein Coupled Receptor Protein Signaling, Phototransduction