MPDZ anticorps (AA 388-480) (Biotin)

N° du produit ABIN1395157

Détail du produit anti-MPDZ anticorps (Biotin)

Antigène: MPDZ (Multiple PDZ Domain Protein (MPDZ))

Épitope: AA 388-480

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp MPDZ est conjugé à/à la Biotin

Application: ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Réactivité croisée: Humain

Homologie: Mouse,Rat,Dog,Cow,Sheep,Horse,Rabbit

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic peptide derived from human MUPP1/MPDZ

Isotype: IgG

Information d'application

Indications d'application: IHC-P 1:200-400
IHC-F 1:100-500

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C for 12 months.

Date de péremption: 12 months

Détails sur MPDZ

Antigène: MPDZ (Multiple PDZ Domain Protein (MPDZ))

Autre désignation: MUPP1/MPDZ (MPDZ Produits)

Synonymes: anticorps HYC2, anticorps MUPP1, anticorps AI225843, anticorps B930003D11Rik, anticorps multiple PDZ domain crumbs cell polarity complex component, anticorps multiple PDZ domain protein, anticorps Multiple PDZ domain protein, anticorps inactivation-no-after-potential D protein, anticorps multiple pdz domain protein, putative, anticorps MPDZ, anticorps Mpdz, anticorps mpz-1, anticorps LOC5569990, anticorps Smp_168960

Sujet:

Synonyms: MPDZ, Multi PDZ domain protein 1, Multi-PDZ domain protein 1, multiple PDZ domain protein, MPDZ_HUMAN.

Background: MPDZ is a 2,042 amino acid peripheral membrane protein that colocalizes with SR-2C on the apical membrane of epithelial choroid plexus cells. Expressed in heart, brain, placenta, liver, skeletal muscle, kidney and pancreas, MPDZ causes clustering of SR-2C, a serotonin receptor, at the cell surface. MPDZ is member of the NMDAR signaling complex that is involved in regulating AMPAR potentiation and synaptic plasticity in excitatory synapses. As a tight junction protein in epithelial cells, MPDZ interacts with SSTR3, a G-protein-coupled receptor, to regulate transepithelial permeability in a pertussis toxin sensitive manner. MPDZ, along with Kir4.2, may form a complex with other proteins in the nephron and regulate ion transport. MPDZ contains one L27 domain and thirteen PDZ domains.

Pathways: Synaptic Membrane, Phototransduction