AKAP5 anticorps (AA 611-714) (Biotin)

N° du produit ABIN1397764

Détail du produit anti-AKAP5 anticorps (Biotin)

Antigène: AKAP5 (A Kinase (PRKA) Anchor Protein 5 (AKAP5))

Épitope: AA 611-714

Reactivité: Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp AKAP5 est conjugé à/à la Biotin

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Réactivité croisée: Rat

Homologie: Human,Mouse,Dog,Cow,Pig,Horse,Rabbit

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic peptide derived from human AKAP5

Isotype: IgG

Information d'application

Indications d'application: WB 1:300-5000
IHC-P 1:200-400
IHC-F 1:100-500

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C for 12 months.

Date de péremption: 12 months

Détails sur AKAP5

Antigène: AKAP5 (A Kinase (PRKA) Anchor Protein 5 (AKAP5))

Autre désignation: AKAP5 (AKAP5 Produits)

Classe de substances: Viral Protein

Sujet:

Synonyms: A kinase PRKA anchor protein 5, A kinase anchor protein 5, A kinase anchor protein 79 kDa, A kinase anchoring protein 75/79, A-kinase anchor protein 5, A-kinase anchor protein 79 kDa, AKAP 5, AKAP 75, AKAP 79, AKAP-5, Akap5, AKAP5_HUMAN, AKAP75, AKAP79, cAMP dependent protein kinase regulatory subunit II high affinity binding protein, cAMP-dependent protein kinase regulatory subunit II high affinity-binding protein, H21.

Background: The type II cAMP-protein kinase (PKA) is a multifunctional kinase with a broad range of substrates (1). Specificity of PKA signaling is thought to be mediated by the compartmentalization of the kinase to specific sites within the cell. To maintain this specific localization, the R subunit (RII) of PKA interacts with specific RII-anchoring proteins. This family of proteins has been designated A-kinase anchoring proteins (AKAP) (1-3). Members of this family, including MAP2 (microtubule-associated protein 2), neuronally expressed AKAP 79 and AKAP 150, and the DNA binding AKAP 95, display differential tissue specificity and localization (4-6). Evidence suggests that AKAP 79 and AKAP 150 are both capable of anchoring PKA to postsynaptic densities (PSD), which are a network of proteins located on the internal surfaces of excitatory synapses.

ID gène: 9495

UniProt: P24588

Pathways: cAMP Metabolic Process