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MLC1 anticorps (AA 321-377) (AbBy Fluor® 488)

Reactivité: Souris, Rat WB, IF (cc), IF (p) Hôte: Lapin Polyclonal AbBy Fluor® 488
N° du produit ABIN1397899
  • Antigène Tous les produits MLC1
    MLC1
    Épitope
    • 14
    • 14
    • 8
    • 5
    • 1
    • 1
    • 1
    • 1
    AA 321-377
    Reactivité
    • 23
    • 15
    • 15
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    Souris, Rat
    Hôte
    • 37
    • 1
    Lapin
    Clonalité
    • 38
    Polyclonal
    Conjugué
    • 11
    • 5
    • 4
    • 4
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp MLC1 est conjugé à/à la AbBy Fluor® 488
    Application
    • 32
    • 20
    • 12
    • 12
    • 4
    • 3
    • 3
    • 1
    • 1
    Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
     Réactivité croisée
    Souris, Rat
    Homologie
    Human,Dog,Pig,Horse,Rabbit
    Purification
    Purified by Protein A.
    Immunogène
    KLH conjugated synthetic peptide derived from human MLC1
    Isotype
    IgG
  • Indications d'application
    IF(IHC-P) 1:50-200
    IF(IHC-F) 1:50-200
    IF(ICC) 1:50-200
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 μg/μL
    Buffer
    Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
    Agent conservateur
    ProClin
    Précaution d'utilisation
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Stock
    -20 °C
    Stockage commentaire
    Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
    Date de péremption
    12 months
  • Antigène
    MLC1
    Abstract
    MLC1 Produits
    Synonymes
    anticorps LVM, anticorps MLC, anticorps VL, anticorps AW048630, anticorps BB074274, anticorps Kiaa0027-hp, anticorps WKL1, anticorps mKIAA0027, anticorps si:ch211-192n14.1, anticorps megalencephalic leukoencephalopathy with subcortical cysts 1, anticorps megalencephalic leukoencephalopathy with subcortical cysts 1 homolog (human), anticorps MLC1, anticorps Mlc1, anticorps mlc1
    Sujet

    Synonyms: KIAA0027, LVM, Megalencephalic leukoencephalopathy with subcortical cysts 1, Membrane protein MLC1, MLC, MLC-1, MLC1_HUMAN, VL, WKL1.

    Background: MLC1 is a 377 amino acid multi-pass membrane protein that may serve as a non-selective neuronal cation channel in brain. Mutant MLC1 proteins that show impaired folding have been corrected in vitro with the addition of a Ca(2+)-ATPase inhibitor, curcumin. Mutations in the gene encoding MLC1 is the cause of megalencephalic leukoencephalopathy with subcortical cysts, also known as van der Knaap disease, a rare syndrome characterized early in life by progressive brain destruction causing mental retardation and incoordination. Single nucleotide polymorphisms within the MLC1 gene may be associated with periodic catatonia, but there seems to be conflicting evidence on whether or not the gene is implicated in general schizophrenia.

    ID gène
    23209
    UniProt
    Q15049
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