TMPRSS6 anticorps (AA 711-811) (FITC)

N° du produit ABIN1398272

Détail du produit anti-TMPRSS6 anticorps (FITC)

Antigène: TMPRSS6 (Transmembrane Protease, serine 6 (TMPRSS6))

Épitope: AA 711-811

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp TMPRSS6 est conjugé à/à la FITC

Application: Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Homologie: Human,Mouse,Rat,Dog,Cow,Chicken

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic peptide derived from human Matriptase 2

Isotype: IgG

Information d'application

Indications d'application: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Date de péremption: 12 months

Détails sur TMPRSS6

Antigène: TMPRSS6 (Transmembrane Protease, serine 6 (TMPRSS6))

Autre désignation: Matriptase 2 (TMPRSS6 Produits)

Synonymes: anticorps IRIDA, anticorps 1300008A22Rik, anticorps transmembrane protease, serine 6, anticorps transmembrane serine protease 6, anticorps Tmprss6, anticorps TMPRSS6

Sujet:

Synonyms: Matriptase-2, Matriptase2, Membrane type serine proteinase 2, MTSP 2, MTSP2, PVAE354, TMPRSS 6, TMPRSS6, TMPS6_HUMAN, TMSP 6, TMSP6, Transmembrane protease serine 6, Type II Membrane Serine Proteinase 6.

Background: Serine protease which hydrolyzes a range of proteins including type I collagen, fibronectin and fibrinogen. Can also activate urokinase-type plasminogen activator with low efficiency. May play a specialized role in matrix remodeling processes in liver. Required to sense iron deficiency. Overexpression suppresses activation of the HAMP promoter.Involvement in disease:Defects in TMPRSS6 are the cause of iron-refractory iron deficiency anemia (IRIDA), also known as hypochromic microcytic anemia with defect in iron metabolism or hereditary iron-handling disorder or pseudo-iron-deficiency anemia. Key features include congenital hypochromic microcytic anemia, very low mean corpuscular erythrocyte volume, low transferrin saturation, abnormal iron absorption characterized by no hematologic improvement following treatment with oral iron, and abnormal iron utilization characterized by a sluggish, incomplete response to parenteral iron.

ID gène: 164656

Pathways: Transition Metal Ion Homeostasis