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UBE2O anticorps (AA 1201-1292) (AbBy Fluor® 555)

UBE2O Reactivité: Humain IF (cc), IF (p) Hôte: Lapin Polyclonal AbBy Fluor® 555
N° du produit ABIN1398749
  • Antigène Voir toutes UBE2O Anticorps
    UBE2O (Ubiquitin-Conjugating Enzyme E2O (UBE2O))
    Épitope
    • 14
    • 5
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 1201-1292
    Reactivité
    • 34
    • 6
    • 4
    • 3
    • 3
    • 3
    • 3
    • 3
    • 1
    • 1
    • 1
    • 1
    Humain
    Hôte
    • 31
    • 2
    • 1
    Lapin
    Clonalité
    • 32
    • 2
    Polyclonal
    Conjugué
    • 17
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp UBE2O est conjugé à/à la AbBy Fluor® 555
    Application
    • 14
    • 13
    • 12
    • 12
    • 4
    • 4
    • 3
    • 3
    • 2
    • 1
    Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
    Homologie
    Mouse,Rat,Pig,Horse,Chicken
    Purification
    Purified by Protein A.
    Immunogène
    KLH conjugated synthetic peptide derived from human UBE2O/E2 230K
    Isotype
    IgG
    Top Product
    Discover our top product UBE2O Anticorps primaire
  • Indications d'application
    IF(IHC-P) 1:50-200
    IF(IHC-F) 1:50-200
    IF(ICC) 1:50-200
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 μg/μL
    Buffer
    Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
    Agent conservateur
    ProClin
    Précaution d'utilisation
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Stock
    -20 °C
    Stockage commentaire
    Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
    Date de péremption
    12 months
  • Antigène
    UBE2O (Ubiquitin-Conjugating Enzyme E2O (UBE2O))
    Autre désignation
    UBE2O (UBE2O Produits)
    Synonymes
    anticorps e2-230k, anticorps E2-230K, anticorps 9630022H21, anticorps B230113M03Rik, anticorps mKIAA1734, anticorps RGD1310297, anticorps ubiquitin conjugating enzyme E2 O, anticorps ubiquitin-conjugating enzyme E2O, anticorps UBE2O, anticorps ube2o, anticorps Ube2o
    Sujet

    Synonyms: E2 230K, ubiquitin-conjugating enzyme E2O, EC=6.3.2.19, FLJ12878, KIAA1734, Likely Ortholog of Mouse Ubiquitin Conjugating Enzyme, RP23 193A16.5, UBE2O, UBE2O_HUMAN, Ubiquitin carrier protein O, Ubiquitin conjugating enzyme E2 O, ubiquitin conjugating enzyme E2O.

    Background: UBE20, also known as E2-230K, is a 1,292 amino acid member of the uniquitin-conjugating enzyme family that is involved in protein modification. Expressed predominately in heart and skeletal muscle, UBE2O functions to catalyze the ATP-dependent covalent attachment of ubiquitin to select proteins, thereby targeting the ubiquitinated proteins for proteasomal degradation. The gene encoding UBE2O maps to human chromosome 17, which comprises over 2.5 % of the human genome and encodes over 1,200 genes. Two key tumor suppressor genes are associated with chromosome 17, namely, p53 and BRCA1. Tumor suppressor p53 is necessary for maintenance of cellular genetic integrity by moderating cell fate through DNA repair versus cell death. Malfunction or loss of p53 expression is associated with malignant cell growth and Li-Fraumeni syndrome. Like p53, BRCA1 is directly involved in DNA repair, though specifically it is recognized as a genetic determinant of early onset breast cancer and predisposition to cancers of the ovary, colon, prostate gland and fallopian tubes.

    ID gène
    63893
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