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RIT1 anticorps (AA 141-219) (Biotin)

RIT1 Reactivité: Humain WB, ELISA, IHC (p), IHC (fro) Hôte: Lapin Polyclonal Biotin
N° du produit ABIN1398823
  • Antigène Voir toutes RIT1 Anticorps
    RIT1 (Ras-Like Without CAAX 1 (RIT1))
    Épitope
    • 14
    • 9
    • 8
    • 6
    • 5
    • 5
    • 1
    • 1
    • 1
    • 1
    AA 141-219
    Reactivité
    • 42
    • 23
    • 5
    • 5
    • 5
    • 5
    • 5
    • 4
    • 4
    • 3
    • 2
    • 2
    • 1
    Humain
    Hôte
    • 50
    • 4
    Lapin
    Clonalité
    • 51
    • 3
    Polyclonal
    Conjugué
    • 21
    • 5
    • 4
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp RIT1 est conjugé à/à la Biotin
    Application
    • 43
    • 23
    • 13
    • 13
    • 3
    • 2
    • 1
    • 1
    • 1
    Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))
    Homologie
    Human,Mouse,Rat,Dog,Cow,Sheep,Pig,Rabbit
    Purification
    Purified by Protein A.
    Immunogène
    KLH conjugated synthetic peptide derived from human RIT1
    Isotype
    IgG
    Top Product
    Discover our top product RIT1 Anticorps primaire
  • Indications d'application
    WB 1:300-5000
    IHC-P 1:200-400
    IHC-F 1:100-500
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 μg/μL
    Buffer
    Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
    Agent conservateur
    ProClin
    Précaution d'utilisation
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Stock
    -20 °C
    Stockage commentaire
    Store at -20°C for 12 months.
    Date de péremption
    12 months
  • Antigène
    RIT1 (Ras-Like Without CAAX 1 (RIT1))
    Autre désignation
    RIT1 (RIT1 Produits)
    Synonymes
    anticorps NS8, anticorps RIBB, anticorps RIT, anticorps ROC1, anticorps RIT1, anticorps rit1, anticorps MGC79097, anticorps RGD1559874, anticorps si:ch211-93a2.3, anticorps Rit, anticorps Ras like without CAAX 1, anticorps Ras-like without CAAX 1 L homeolog, anticorps Ras-like without CAAX 1, anticorps RIT1, anticorps rit1.L, anticorps Rit1, anticorps rit1
    Sujet

    Synonyms: GTP binding protein Roc1, GTP-binding protein Rit1, Ras like protein expressed in many tissues, Ras like without CAAX 1, Ras-like protein expressed in many tissues, Ras-like without CAAX protein 1, RIBB, Ric like expressed in many tissues, RIT, RIT1, RIT1_HUMAN, ROC1.

    Background: Plays a crucial role in coupling NGF stimulation to the activation of both EPHB2 and MAPK14 signaling pathways and in NGF-dependent neuronal differentiation.Neuronal activity dramatically increases the concentration of cytosolic Ca2+, which then serves as a second messenger to direct diverse cellular responses. Calmodulin is a primary mediator of Ca2+ signals in the nervous system. Ric, a protein related to the Ras subfamily of small GTPases, has the ability to bind calmodulin. In addition, two Ras-like human proteins, Rin and Rit (Ric-related gene expressed in many tissues), which are 71 % and 66 % identical to RIC respectively, share related G2 domains with Ric. While most members of the Ras subfamily are plasma membrane-associated and generally require a C-terminal isoprenyl group to bind to the plasma membrane, Rit and Rin lack the recognition signal for C-terminal prenylation. Transiently expressed Rit and Rin are plasma membrane-localized because both proteins contain a C-terminal cluster of basic amino acids, which provides a mechanism for membrane association. Rin binds calmodulin through a C-terminal binding motif. Rit and Ric are widely expressed, whereas expression of Rin is restricted to the neuron system. In conclusion, Rit and Rin define a novel subfamily of Ras-related proteins

    ID gène
    6016
    Pathways
    Neurotrophin Signaling Pathway
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