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HOXD9 anticorps (AA 251-352) (AbBy Fluor® 488)

HOXD9 Reactivité: Humain WB, IF (p), IF (cc) Hôte: Lapin Polyclonal AbBy Fluor® 488
N° du produit ABIN1399972
  • Antigène Voir toutes HOXD9 Anticorps
    HOXD9 (Homeobox D9 (HOXD9))
    Épitope
    • 14
    • 12
    • 12
    • 7
    • 7
    • 6
    • 6
    • 6
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    AA 251-352
    Reactivité
    • 49
    • 26
    • 21
    • 9
    • 4
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    Humain
    Hôte
    • 61
    • 2
    Lapin
    Clonalité
    • 61
    • 2
    Polyclonal
    Conjugué
    • 19
    • 7
    • 7
    • 6
    • 4
    • 4
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp HOXD9 est conjugé à/à la AbBy Fluor® 488
    Application
    • 51
    • 36
    • 12
    • 12
    • 3
    • 3
    • 3
    • 1
    Western Blotting (WB), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunofluorescence (Cultured Cells) (IF (cc))
    Homologie
    Human,Mouse,Rat,Dog,Cow,Pig,Chicken,Rabbit
    Purification
    Purified by Protein A.
    Immunogène
    KLH conjugated synthetic peptide derived from human HOXD9
    Isotype
    IgG
    Top Product
    Discover our top product HOXD9 Anticorps primaire
  • Indications d'application
    IF(IHC-P) 1:50-200
    IF(IHC-F) 1:50-200
    IF(ICC) 1:50-200
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 μg/μL
    Buffer
    Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
    Agent conservateur
    ProClin
    Précaution d'utilisation
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Stock
    -20 °C
    Stockage commentaire
    Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
    Date de péremption
    12 months
  • Antigène
    HOXD9 (Homeobox D9 (HOXD9))
    Autre désignation
    HOXD9 (HOXD9 Produits)
    Synonymes
    anticorps Hox-4.4, anticorps Hox-5.2, anticorps Xhoxd9, anticorps HOX4, anticorps HOX4C, anticorps Hox-4.3, anticorps hoxd9, anticorps z-28, anticorps hoxd9a, anticorps homeobox D9, anticorps homeobox D9 S homeolog, anticorps homeo box D9, anticorps homeobox D9a, anticorps Hoxd9, anticorps HOXD9, anticorps hoxd9.S, anticorps hoxd9a, anticorps hoxd9
    Sujet

    Synonyms: homeobox D9, Homeobox protein Hox D9, Hox 4.3, Hox 5.2, HOX4, HOX4C, RP23 313J15.10, HXD9_HUMAN.

    Background: The Hox proteins play a role in patterns of embryonic development and cellular differentiation by regulating downstream target genes. In vivo, the HoxD9 protein interacts with the autoregulatory and cross-regulatory enhancers of the murine HoxB1 and human HoxD9 genes. Specifically, the HoxD9 protein interacts with the human control region (HCR) of the HoxD9 gene, thus inducing transcription of the HoxD9 promoter. HoxD9 may be a multifunctional transcriptional regulator, as it contains different activation domains. Activation of HoxD9 depends on the structure of the target regulatory element, and results in differential cofactor interaction. The HoxD9 protein is expressed in the early stages of mouse joint development, primarily in the articular cartilage. HoxD9 transcripts are also detected in the synovial tissue of arthritic mice, but not in that of normal mice, suggesting that HoxD9 may have a role in the pathology of arthritis. Furthermore, the HoxD9 protein is highly expressed in the synoviocytes of patients with rheumatoid arthritis (RA), but not in osteoarthritis patients. The human HoxD9 protein is also differentially expressed in the human cervical cancer cell line HeLa, but is not expressed in the normal cervix and may thus play a role in tumorigenesis.

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