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IQCG anticorps (AbBy Fluor® 555)

IQCG Reactivité: Humain, Souris, Rat WB, IF (p) Hôte: Lapin Polyclonal AbBy Fluor® 555
N° du produit ABIN1400387
  • Antigène Voir toutes IQCG Anticorps
    IQCG (IQ Motif Containing G (IQCG))
    Reactivité
    Humain, Souris, Rat
    Hôte
    • 20
    Lapin
    Clonalité
    • 20
    Polyclonal
    Conjugué
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp IQCG est conjugé à/à la AbBy Fluor® 555
    Application
    • 16
    • 12
    • 5
    • 3
    • 1
    • 1
    Western Blotting (WB), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
     Réactivité croisée
    Humain, Souris, Rat
    Purification
    Purified by Protein A.
    Immunogène
    KLH conjugated synthetic peptide derived from human IQCG
    Isotype
    IgG
    Top Product
    Discover our top product IQCG Anticorps primaire
  • Indications d'application
    IF(IHC-P) 1:50-200
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 μg/μL
    Buffer
    Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
    Agent conservateur
    ProClin
    Précaution d'utilisation
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Stock
    -20 °C
    Stockage commentaire
    Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
    Date de péremption
    12 months
  • Antigène
    IQCG (IQ Motif Containing G (IQCG))
    Autre désignation
    IQCG (IQCG Produits)
    Synonymes
    anticorps 2400003L07Rik, anticorps RGD1311606, anticorps IQ motif containing G, anticorps IQCG, anticorps iqcg, anticorps Iqcg
    Sujet

    Synonyms: IQ domain containing protein G, IQ mot containing G, DKFZp434B227, FLJ11667, FLJ23571, FLJ37775, IQCG_HUMAN.

    Background: IQCG is a 443 amino acid protein containing one IQ domain. Widely distributed in nature, the IQ domain forms an amphiphilic seven-turn -helix capable of binding calmodulin in a Ca2+-independent manner. The level of intracellular calcium is tightly regulated in all eukaryotic cells. A modest increase in this level can result in a myriad of physiological responses, most of which are mediated by calmodulin (CaM), the universal calcium sensor. In acute T-lymphoid/myeloid leukemia, IQCG forms a complex with Nup98, an O-linked glycoprotein and a component of the nuclear pore complex. NUP98-IQCG complex bind co-activators and/or co-repressors, which suggest a role in transcriptional regulation.Nup98-IQCG complex inhibits 32Dcl3 cell apoptosis induced by Arabinofuranosylcytosine (Ara-C) and partially blocks granulocyte differentiation induced by G-CSF. IQCG exists as two isoforms due to alternatively splicing events.

    ID gène
    84223
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