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DIS3L anticorps (AbBy Fluor® 488)

DIS3L Reactivité: Humain, Souris, Rat WB, IF (p) Hôte: Lapin Polyclonal AbBy Fluor® 488
N° du produit ABIN1400554
  • Antigène Voir toutes DIS3L Anticorps
    DIS3L (DIS3-Like Exonuclease 1 (DIS3L))
    Reactivité
    Humain, Souris, Rat
    Hôte
    • 34
    • 3
    Lapin
    Clonalité
    • 37
    Polyclonal
    Conjugué
    • 10
    • 5
    • 4
    • 4
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp DIS3L est conjugé à/à la AbBy Fluor® 488
    Application
    • 32
    • 17
    • 14
    • 12
    • 5
    Western Blotting (WB), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
     Réactivité croisée
    Humain, Souris, Rat
    Purification
    Purified by Protein A.
    Immunogène
    KLH conjugated synthetic peptide derived from human DIS3L
    Isotype
    IgG
    Top Product
    Discover our top product DIS3L Anticorps primaire
  • Indications d'application
    IF(IHC-P) 1:50-200
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 μg/μL
    Buffer
    Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
    Agent conservateur
    ProClin
    Précaution d'utilisation
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Stock
    -20 °C
    Stockage commentaire
    Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
    Date de péremption
    12 months
  • Antigène
    DIS3L (DIS3-Like Exonuclease 1 (DIS3L))
    Autre désignation
    DIS3L (DIS3L Produits)
    Synonymes
    anticorps DIS3L1, anticorps AV340375, anticorps RGD1308959, anticorps zgc:158615, anticorps DIS3 like exosome 3'-5' exoribonuclease, anticorps DIS3-like exosome 3'-5' exoribonuclease, anticorps DIS3L, anticorps dis3l, anticorps Dis3l, anticorps dis3l.L
    Sujet

    Synonyms: DIS3 like exonuclease 1, DIS3 mitotic control homolog S. cerevisiae like, FLJ38088, KIAA1955, MGC4562, DI3L1_HUMAN.

    Background: The exosome is a multi-protein complex composed of several highly conserved subunits, some of which are 3? to 5? exoribonucleases. The complex is involved in a variety of cellular processes and is responsible for degrading unstable mRNAs that contain AU-rich elements (AREs) in their untranslated 3? regions. DIS3, also known as RRP44, is a 958 amino acid protein that localizes to both the cytoplasm and the nucleus and contains one PINc domain. Widely expressed with highest expression in testis, DIS3 functions as a component of the exosome exoribonuclease complex and is required for processing of 7S pre-RNA into a mature nuclear complex and, ultimately, for proper mitotic progression. Abnormal expression levels of DIS3 may be associated with colon cancer, suggesting a role for DIS3 in tumorigenesis. Multiple isoforms of DIS3 exist due to alternative splicing events.

    ID gène
    115752
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