HIP1R anticorps (Biotin)

N° du produit ABIN1400647

Détail du produit anti-HIP1R anticorps (Biotin)

Antigène: HIP1R (Huntingtin Interacting Protein 1 Related (HIP1R))

Reactivité: Humain, Rat, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp HIP1R est conjugé à/à la Biotin

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Réactivité croisée: Humain, Souris, Rat

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic peptide derived from human HIP1R/HIP12/HIP3

Isotype: IgG

Information d'application

Indications d'application: WB 1:300-5000
IHC-P 1:200-400

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C for 12 months.

Date de péremption: 12 months

Détails sur HIP1R

Antigène: HIP1R (Huntingtin Interacting Protein 1 Related (HIP1R))

Autre désignation: HIP12 (HIP1R Produits)

Synonymes: anticorps HIP12, anticorps HIP3, anticorps ILWEQ, anticorps AA410023, anticorps mKIAA0655, anticorps HIP1R, anticorps hip1r, anticorps hip3, anticorps hip12, anticorps ilweq, anticorps DKFZp469N2015, anticorps hip1, anticorps MGC78813, anticorps huntingtin interacting protein 1 related, anticorps huntingtin interacting protein 1 related b, anticorps huntingtin interacting protein 1 related L homeolog, anticorps HIP1R, anticorps Hip1r, anticorps hip1rb, anticorps hip1r, anticorps hip1r.L

Sujet:

Synonyms: Hip1 related, HIP12, HIP3, Huntingtin Interacting Protein 1 Related, HIP1R, Huntingtin interacting protein 12, HIP1R_HUMAN.

Background: Huntington disease is associated with the expansion of a polyglutamine tract, greater than 35 repeats, in the HD gene product, huntingtin. HIP1, a membrane-associated protein, binds specifically to the N-terminus of human huntingtin. HIP1 is ubiquitously expressed in different brain regions at low levels and exhibits nearly identical subcellular fractionation as huntingtin. The HIP1 gene locates to the human chromosome 7q11.23. The huntingtin-HIP1 interaction is restricted to the brain and is inversely correlated to the polyglutamine length in the huntingtin, suggesting that loss of normal huntingtin-HIP1 interaction may compromise the membrane-cytoskeletal integrity in the brain. HIP1 contains an endocytic multidomain protein with a C-terminal Actin-binding domain, a central coiled-coil forming region and an N-terminal ENTH domain. HIP1 may be involved in vesicle trafficking, the structural integrity of HIP1 is crucial for maintenance of normal vesicle size in vivo. HIP12 is a non-proapoptotic member of the HIP gene family that is expressed in the brain and shares a similar subcellular distribution pattern with HIP1. However, HIP12 differs from HIP1 in its pattern of expression at both the mRNA and protein level. HIP12 does not directly interact with huntingtin but can interact with HIP1.

ID gène: 9026