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Tankyrase anticorps (AA 1140-1171) (AbBy Fluor® 555)

Reactivité: Humain, Souris, Rat WB, IF (p) Hôte: Lapin Polyclonal AbBy Fluor® 555
N° du produit ABIN1400861
  • Antigène Tous les produits Tankyrase
    Tankyrase
    Épitope
    • 14
    • 2
    • 1
    • 1
    AA 1140-1171
    Reactivité
    Humain, Souris, Rat
    Hôte
    • 17
    • 2
    Lapin
    Clonalité
    • 17
    • 2
    Polyclonal
    Conjugué
    • 6
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp Tankyrase est conjugé à/à la AbBy Fluor® 555
    Application
    • 19
    • 12
    • 4
    • 4
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
     Réactivité croisée
    Humain, Souris, Rat
    Purification
    Purified by Protein A.
    Immunogène
    KLH conjugated synthetic peptide derived from human Tankyrase
    Isotype
    IgG
  • Indications d'application
    IF(IHC-P) 1:50-200
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 μg/μL
    Buffer
    Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
    Agent conservateur
    ProClin
    Précaution d'utilisation
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Stock
    -20 °C
    Stockage commentaire
    Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
    Date de péremption
    12 months
  • Antigène
    Tankyrase
    Abstract
    Tankyrase Produits
    Synonymes
    anticorps BcDNA:LD22548, anticorps CG17487, anticorps CG4719, anticorps Dm.pARTb, anticorps Dmel\\CG4719, anticorps GB12086, anticorps tankyrase, anticorps Tnks, anticorps LOC413032, anticorps LOC5578003, anticorps CpipJ_CPIJ017909
    Sujet

    Synonyms: TIN1, ARTD5, PARPL, TINF1, TNKS1, pART5, PARP5A, PARP-5a, Tankyrase-1, TANK1, ADP-ribosyltransferase diphtheria toxin-like 5, Poly [ADP-ribose] polymerase 5A, TNKS-1, TRF1-interacting ankyrin-related ADP-ribose polymerase, Tankyrase I, TNKS

    Background: Poly-ADP-ribosyltransferase involved in various processes such as Wnt signaling pathway, telomere length and vesicle trafficking. Acts as an activator of the Wnt signaling pathway by mediating poly-ADP-ribosylation (PARsylation) of AXIN1 and AXIN2, 2 key components of the beta-catenin destruction complex: poly-ADP-ribosylated target proteins are recognized by RNF146, which mediates their ubiquitination and subsequent degradation. Also mediates PARsylation of BLZF1 and CASC3, followed by recruitment of RNF146 and subsequent ubiquitination. Mediates PARsylation of TERF1, thereby contributing to the regulation of telomere length. Involved in centrosome maturation during prometaphase by mediating PARsylation of HEPACAM2/MIKI. May also regulate vesicle trafficking and modulate the subcellular distribution of SLC2A4/GLUT4-vesicles. May be involved in spindle pole assembly through PARsylation of NUMA1. Stimulates 26S proteasome activity.

    ID gène
    8658
    UniProt
    O95271
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