COPS6 anticorps (Biotin)

N° du produit ABIN1400947

Détail du produit anti-COPS6 anticorps (Biotin)

Antigène: COPS6 (COP9 Signalosome Complex Subunit 6 (COPS6))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp COPS6 est conjugé à/à la Biotin

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Réactivité croisée: Humain, Souris, Rat

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic peptide derived from human COPS6

Isotype: IgG

Information d'application

Indications d'application: WB 1:300-5000
IHC-P 1:200-400

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C for 12 months.

Date de péremption: 12 months

Détails sur COPS6

Antigène: COPS6 (COP9 Signalosome Complex Subunit 6 (COPS6))

Autre désignation: COPS6 (COPS6 Produits)

Synonymes: anticorps CG6932, anticorps CH6, anticorps Csn6, anticorps Dch6, anticorps Dmel\\CG6932, anticorps zgc:112075, anticorps Sgn3, anticorps VIP/MOV34, anticorps CSN6, anticorps MOV34-34KD, anticorps COP9 signalosome subunit 6, anticorps COP-9 SigNalosome subunit, anticorps COPS6, anticorps Cops6, anticorps CSN6, anticorps cops6, anticorps csn-6

Sujet:

Synonyms: JAB1 containing signalosome subunit 6,COP9 subunit 6 MOV34 homolog, 34 kD,MOV34 homolog, 34 kD,COP9 constitutive photomorphogenic, subunit 6, COP9 complex S6,COP9 signalosome complex subunit 6,COP9 signalosome subunit 6,cops6,CSN6,CSN6_HUMAN,hVIP,JAB1-containing signalosome subunit 6,MOV34 homolog,MOV34-34KD,Sgn3,SGN6,Signalosome subunit 6,VIP/MOV34,Vpr interacting protein,Vpr-interacting protein.

Background: Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. Has some glucocorticoid receptor-responsive activity.

ID gène: 10980

Pathways: Cycle Cellulaire