TRIM11 anticorps (AbBy Fluor® 350)
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- Antigène Voir toutes TRIM11 Anticorps
- TRIM11 (Tripartite Motif Containing 11 (TRIM11))
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Reactivité
- Humain, Souris, Rat
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp TRIM11 est conjugé à/à la AbBy Fluor® 350
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Application
- Western Blotting (WB), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
- Réactivité croisée
- Humain, Souris, Rat
- Purification
- Purified by Protein A.
- Immunogène
- KLH conjugated synthetic peptide derived from human TRIM11/RNF92
- Isotype
- IgG
- Top Product
- Discover our top product TRIM11 Anticorps primaire
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- Indications d'application
- IF(IHC-P) 1:50-200
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1 μg/μL
- Buffer
- Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
- Agent conservateur
- ProClin
- Précaution d'utilisation
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
- Stock
- -20 °C
- Stockage commentaire
- Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
- Date de péremption
- 12 months
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- Antigène
- TRIM11 (Tripartite Motif Containing 11 (TRIM11))
- Autre désignation
- RNF92 (TRIM11 Produits)
- Synonymes
- anticorps BIA1, anticorps RNF92, anticorps TRIM11, anticorps tripartite motif containing 11, anticorps tripartite motif-containing 11, anticorps TRIM11, anticorps Trim11
- Sujet
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Synonyms: BIA 1, E3 ubiquitin protein ligase TRIM11, E3 ubiquitin-protein ligase TRIM11, Protein BIA1, RING finger protein 92, RNF 92, TRI11_HUMAN, Trim 11, TRIM11, Tripartite mot containing 11, tripartite mot protein 11, Tripartite mot-containing protein 11.
Background: E3 ubiquitin-protein ligase that promotes the degradation of insoluble ubiquitinated proteins, including insoluble PAX6, poly-Gln repeat expanded HTT and poly-Ala repeat expanded ARX. Mediates PAX6 ubiquitination leading to proteasomal degradation, thereby modulating cortical neurogenesis. May also inhibit PAX6 transcriptional activity, possibly in part by preventing the binding of PAX6 to its consensus sequences. May contribute to the regulation of the intracellular level of HN (humanin) or HN-containing proteins through the proteasomal degradation pathway. Mediates MED15 ubiquitination leading to proteasomal degradation. May contribute to the innate restriction of retroviruses. Upon overexpression, reduces HIV-1 and murine leukemia virus infectivity, by suppressing viral gene expression. Antiviral activity depends on a functional E3 ubiquitin-protein ligase domain. May regulate TRIM5 turnover via the proteasome pathway, thus counteracting the TRIM5-mediated cross-species restriction of retroviral infection at early stages of the retroviral life cycle.
- ID gène
- 81559
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