C18orf1 anticorps (AA 1-50) (Biotin)

N° du produit ABIN1403881

Détail du produit anti-C18orf1 anticorps (Biotin)

Antigène: C18orf1 (Chromosome 18 Open Reading Frame 1 (C18orf1))

Épitope: AA 1-50

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp C18orf1 est conjugé à/à la Biotin

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Réactivité croisée: Humain, Souris, Rat

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic peptide derived from human C18orf1

Isotype: IgG

Information d'application

Indications d'application: WB 1:300-5000
IHC-P 1:200-400

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C for 12 months.

Date de péremption: 12 months

Détails sur C18orf1

Antigène: C18orf1 (Chromosome 18 Open Reading Frame 1 (C18orf1))

Autre désignation: C18orf1 (C18orf1 Produits)

Synonymes: anticorps C18orf1, anticorps 8230401C20Rik, anticorps A430083H02, anticorps A430108L08Rik, anticorps D18Ertd653e, anticorps D330030L18Rik, anticorps low density lipoprotein receptor class A domain containing 4, anticorps LDLRAD4, anticorps Ldlrad4

Sujet:

Synonyms: C18orf1, Low-density lipoprotein receptor class A domain-containing protein 4, LDLRAD4

Background: Functions as a negative regulator of TGF-beta signaling and thereby probably plays a role in cell proliferation, differentiation, apoptosis, motility, extracellular matrix production and immunosuppression. In the canonical TGF-beta pathway, ZFYVE9/SARA recruits the intracellular signal transducer and transcriptional modulators SMAD2 and SMAD3 to the TGF-beta receptor. Phosphorylated by the receptor, SMAD2 and SMAD3 then form a heteromeric complex with SMAD4 that translocates to the nucleus to regulate transcription. Through interaction with SMAD2 and SMAD3, LDLRAD4 may compete with ZFYVE9 and SMAD4 and prevent propagation of the intracellular signal.

ID gène: 753

UniProt: O15165