TSEN2 anticorps (Biotin)

N° du produit ABIN1404361

Détail du produit anti-TSEN2 anticorps (Biotin)

Antigène: TSEN2 (tRNA-splicing Endonuclease Subunit SEN2 (TSEN2))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp TSEN2 est conjugé à/à la Biotin

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Réactivité croisée: Humain, Souris, Rat

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic peptide derived from human TSEN2

Isotype: IgG

Information d'application

Indications d'application: WB 1:300-5000
IHC-P 1:200-400

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C for 12 months.

Date de péremption: 12 months

Détails sur TSEN2

Antigène: TSEN2 (tRNA-splicing Endonuclease Subunit SEN2 (TSEN2))

Autre désignation: TSEN2 (TSEN2 Produits)

Synonymes: anticorps AU067695, anticorps RGD1309946, anticorps PCH2B, anticorps SEN2, anticorps SEN2L, anticorps tRNA splicing endonuclease subunit 2, anticorps TSEN2, anticorps Tsen2

Sujet:

Synonyms: HsSen2, MGC2776, MGC4440, SEN2, SEN2L, tRNA intron endonuclease Sen2, tRNA splicing endonuclease 2 homolog SEN2, S. cerevisiae, tRNA splicing endonuclease subunit Sen2, TSEN 2, SEN2_HUMAN.

Background: The tRNA-splicing endonuclease complex is responsible for identifying and cleaving pre-tRNA at both 5? and 3? splice sites, thereby releasing introns and free tRNA molecules with 2',3' cyclic phosphates and 5'-OH termini. In addition to its role in pre-tRNA splicing, the heterotetrameric endonuclease complex participates in mRNA processing and, via its association with pre-mRNA processing factors, is thought to link pre-tRNA and pre-mRNA splicing events. TSEN2 (tRNA-splicing endonuclease subunit Sen2), also known as tRNA-intron endonuclease Sen2, is a 465 amino acid nuclear protein that constitutes one of the two catalytic subunits of the tRNA-splicing endonuclease complex. There are three isoforms of TSEN2 that are produced as a result of alternative splicing events. Isoform 1 seems to carry the active site for 5?-splice site cleavage. Defects in the gene encoding TSEN2 are the cause of pontocerebellar hypoplasia type 2B, which is characterized by progressive microencephaly with epilepsy, extrapyramidal dyskinesia and chorea without spinal cord findings.

ID gène: 80746

Pathways: Nuclear Receptor Transcription Pathway, Regulation of Lipid Metabolism by PPARalpha