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ANKRD13B anticorps (AbBy Fluor® 647)

ANKRD13B Reactivité: Humain, Souris, Rat WB, IF (p) Hôte: Lapin Polyclonal AbBy Fluor® 647
N° du produit ABIN1404420
  • Antigène Tous les produits ANKRD13B
    ANKRD13B (Ankyrin Repeat Domain 13B (ANKRD13B))
    Reactivité
    • 19
    • 17
    • 17
    • 2
    • 1
    • 1
    • 1
    Humain, Souris, Rat
    Hôte
    • 19
    Lapin
    Clonalité
    • 19
    Polyclonal
    Conjugué
    • 6
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp ANKRD13B est conjugé à/à la AbBy Fluor® 647
    Application
    • 19
    • 12
    • 3
    • 2
    • 1
    Western Blotting (WB), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
     Réactivité croisée
    Humain, Souris, Rat
    Purification
    Purified by Protein A.
    Immunogène
    KLH conjugated synthetic peptide derived from human ANKRD13B
    Isotype
    IgG
  • Indications d'application
    IF(IHC-P) 1:50-200
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 μg/μL
    Buffer
    Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
    Agent conservateur
    ProClin
    Précaution d'utilisation
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Stock
    -20 °C
    Stockage commentaire
    Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
    Date de péremption
    12 months
  • Antigène
    ANKRD13B (Ankyrin Repeat Domain 13B (ANKRD13B))
    Autre désignation
    ANKRD13B (ANKRD13B Produits)
    Synonymes
    anticorps zgc:113371, anticorps AW124583, anticorps B930093C12Rik, anticorps RGD1564005, anticorps ankyrin repeat domain 13B, anticorps ankyrin repeat domain 13B L homeolog, anticorps ankyrin repeat domain 13b, anticorps ANKRD13B, anticorps ankrd13b, anticorps ankrd13b.L, anticorps Ankrd13b
    Sujet

    Synonyms: Ankrd13b, ANKRD13Bankyrin repeat domain 13B, ankyrin repeat domain 13B, AN13B_HUMAN.

    Background: Ankyrins are membrane adaptor molecules that play important roles in coupling integral membrane proteins to the spectrin-based cytoskeleton network. Mutations of ankyrin genes can lead to severe genetic diseases, such as fatal cardiac arrhythmias and hereditary spherocytosis. ANKRD13B (ankyrin repeat domain 13B) is a 626 amino acid protein that contains two ANK repeats and three ubiquitin-interacting motif (UIM) repeats. Conserved in dog, cow, mouse and rat, ANKRD13B exists as two alternatively spliced isoforms. The gene that encodes ANKRD13B maps to human chromosome 17, which makes up over 2.5 % of the human genome, with about 81 million bases encoding over 1,200 genes. Two key tumor suppressor genes are associated with chromosome 17, namely, p53 and BRCA1. Malfunction or loss of p53 expression is associated with malignant cell growth and Li-Fraumeni syndrome. BRCA1 is recognized as a genetic determinant of early onset breast cancer. Chromosome 17 is also linked to neurofibromatosis, dysregulated Schwann cell growth, Alexander disease, Birt-Hogg-Dube syndrome and Canavan disease.

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