CLEC11A anticorps (AbBy Fluor® 647)
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- Antigène Voir toutes CLEC11A Anticorps
- CLEC11A (C-Type Lectin Domain Family 11, Member A (CLEC11A))
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Reactivité
- Humain, Souris, Rat
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp CLEC11A est conjugé à/à la AbBy Fluor® 647
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Application
- Western Blotting (WB), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
- Réactivité croisée
- Humain, Souris, Rat
- Purification
- Purified by Protein A.
- Immunogène
- KLH conjugated synthetic peptide derived from human Pleckstrin/p47
- Isotype
- IgG
- Top Product
- Discover our top product CLEC11A Anticorps primaire
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- Indications d'application
- IF(IHC-P) 1:50-200
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1 μg/μL
- Buffer
- Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
- Agent conservateur
- ProClin
- Précaution d'utilisation
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
- Stock
- -20 °C
- Stockage commentaire
- Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
- Date de péremption
- 12 months
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- Antigène
- CLEC11A (C-Type Lectin Domain Family 11, Member A (CLEC11A))
- Autre désignation
- p47 (CLEC11A Produits)
- Synonymes
- anticorps CLEC11A, anticorps CLECSF3, anticorps LSLCL, anticorps P47, anticorps SCGF, anticorps AW457320, anticorps Clecsf3, anticorps Scgf, anticorps C-type lectin domain containing 11A, anticorps C-type lectin domain family 11, member a, anticorps CLEC11A, anticorps Clec11a
- Sujet
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Synonyms: p47, Platelet 47 kDa protein, Platelet and leukocyte C kinase substrate, Platelet P47, Platelet p47 protein, Pleckstrin, PLEK, PLEK_HUMAN, FLJ27168, OTTHUMP00000159962.
Background: Platelet P47, also known as NSFL1C, UBX1, UBXD10 or UBXN2C, is a 370 amino acid protein that localizes to both the nucleus and the golgi apparatus (specifically to golgi stacks) and contains one SEP domain and one UBX domain. Functioning as part of a ternary complex with VCP (a protein involved in the heterotypic fusion of transport vesicles with their target membranes) and Syntaxin 5, p47 interacts with and reduces the ATPase activity of VCP and is required for the fragmentation of golgi stacks during mitosis and for subsequent reassembly of golgi stacks after mitosis. p47 is subject to phosphorylation during mitosis, which inhibits p47-golgi interaction and is, therefore, required for proper golgi stack formation and cisternal regrowth. Human p47 shares 89 % sequence identity with its mouse counterpart, suggesting a conserved role between species. Multiple isoforms of p47 exist due to alternative splicing events.
- ID gène
- 5341
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