Humainin anticorps (AA 1-24) (Cy3)

N° du produit ABIN1410393

Détail du produit anti-Humanin anticorps (Cy3)

Antigène: Humanin (MT-RNR2) (Mitochondrially Encoded 16S RNA (MT-RNR2))

Épitope: AA 1-24

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Humanin est conjugé à/à la Cy3

Application: Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunofluorescence (Cultured Cells) (IF (cc))

Homologie: Human

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic peptide derived from human Humanin

Isotype: IgG

Information d'application

Indications d'application: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: -20 °C/-80 °C

Stockage commentaire: Store at -20°C, for long storage, store at -80°C. Avoid multiple freeze-thaw cycles

Date de péremption: 12 months

Détails sur Humanin

Antigène: Humanin (MT-RNR2) (Mitochondrially Encoded 16S RNA (MT-RNR2))

Autre désignation: Humanin (MT-RNR2 Produits)

Synonymes: anticorps MTRNR2, anticorps l-rRNA, anticorps RNR2

Sujet:

Humanin, an endogenous anti-apoptotic peptide against Alzheimer disease-related insults, consists of 24 amino acids. The secreted protein is a neuroprotective factor against death induced by several different types of Alzheimer's disease genes. Humanin protects neuronal cells from damage caused by Alzheimer's disease genes, specifically APP (amyloid precursor protein). Humanin acts as a ligand for formyl peptide receptor-like 1 (FPRL1) with APP and utilizes its neuroprotective effects by inhibiting FPRL1 access to APP. The peptide prevents Bax translocation from cytosol to mitochondria. Humanin expression levels may be dependent on defects in energy production in muscles with mitochondrial abnormalities. The peptide has been detected in muscles of patients with the mitochondrial disease chronic progressive external ophthalmoplegia (CPEO). Humanin is mainly expressed in the kidney, heart, liver, testis and skeletal muscles.

Subcellular location: Secreted

Synonyms: HN,HUNIN, HUNIN_HUMAN.