PHYHIP anticorps (AA 231-330) (Cy3)

N° du produit ABIN1412025

Détail du produit anti-PHYHIP anticorps (Cy3)

Antigène: PHYHIP (Phytanoyl-CoA 2-Hydroxylase Interacting Protein (PHYHIP))

Épitope: AA 231-330

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp PHYHIP est conjugé à/à la Cy3

Application: Western Blotting (WB), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunofluorescence (Cultured Cells) (IF (cc))

Homologie: Human,Mouse,Rat,Dog,Cow,Pig,Horse,Rabbit

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic peptide derived from human PHYHIP

Isotype: IgG

Information d'application

Indications d'application: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Date de péremption: 12 months

Détails sur PHYHIP

Antigène: PHYHIP (Phytanoyl-CoA 2-Hydroxylase Interacting Protein (PHYHIP))

Autre désignation: PHYHIP (PHYHIP Produits)

Synonymes: anticorps PHYHIP, anticorps DYRK1AP3, anticorps PAHX-AP, anticorps PAHXAP1, anticorps AW049870, anticorps C630010D02Rik, anticorps Lnap1ip, anticorps PAHX-AP1, anticorps phytanoyl-CoA 2-hydroxylase interacting protein, anticorps phytanoyl-CoA hydroxylase interacting protein, anticorps PHYHIP, anticorps phyhip, anticorps Phyhip

Sujet:

Synonyms: DYRK1A interacting protein 3, DYRK1AP3, PAHX AP1, PAHXAP1, phytanoyl CoA 2 hydroxylase interacting protein, phytanoyl CoA alpha hydroxylase associated protein, Phytanoyl CoA hydroxylase associated protein 1, Phytanoyl CoA hydroxylase interacting protein, Similar to a putative C.elegans gene encoded in cosmid M01B2, PHYIP_HUMAN.

Background: PHYHIP (Phytanoyl-CoA hydroxylase-interacting protein) is a 330 amino acid protein that is strongly expressed in brain, with weak expression in ovary, small intestine and ovary. In transgenic mice, overexpression of PHYHIP in heart results in tachycardia and tachyarrhythmia. PHYHIP interacts with the Refsum disease gene product, PAHX, indicating that PHYHIP may play a role in the CNS deficits of Refsum disease, which is characterized by cerebellar degeneration, neurologic damage and peripheral neuropathies. PHYHIP also interacts with Dyrk1A, a protein that that is overexpressed in brain of Down-syndrome patients, therefore PHYHIP may participate in some of the neurological abnormalities of Down syndrome. Significantly, the gene encoding PHYHIP is localized to a region of the short arm of human chromosome 8 that is frequently found deleted in prostate, breast and several other types of cancers.