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TMPRSS6 anticorps (AA 711-811) (Cy3)

TMPRSS6 Reactivité: Humain WB, IF (cc), IF (p) Hôte: Lapin Polyclonal Cy3
N° du produit ABIN1416137
  • Antigène Voir toutes TMPRSS6 Anticorps
    TMPRSS6 (Transmembrane Protease, serine 6 (TMPRSS6))
    Épitope
    • 14
    • 9
    • 8
    • 6
    • 5
    • 2
    • 1
    AA 711-811
    Reactivité
    • 50
    • 8
    • 8
    • 5
    • 5
    • 4
    • 2
    • 2
    • 1
    • 1
    Humain
    Hôte
    • 48
    • 2
    Lapin
    Clonalité
    • 50
    Polyclonal
    Conjugué
    • 13
    • 5
    • 4
    • 4
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp TMPRSS6 est conjugé à/à la Cy3
    Application
    • 38
    • 20
    • 12
    • 12
    • 4
    • 3
    • 3
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
    Homologie
    Human,Mouse,Rat,Dog,Cow,Chicken
    Purification
    Purified by Protein A.
    Immunogène
    KLH conjugated synthetic peptide derived from human Matriptase 2
    Isotype
    IgG
    Top Product
    Discover our top product TMPRSS6 Anticorps primaire
  • Indications d'application
    IF(IHC-P) 1:50-200
    IF(IHC-F) 1:50-200
    IF(ICC) 1:50-200
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 μg/μL
    Buffer
    Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
    Agent conservateur
    ProClin
    Précaution d'utilisation
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Stock
    -20 °C
    Stockage commentaire
    Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
    Date de péremption
    12 months
  • Antigène
    TMPRSS6 (Transmembrane Protease, serine 6 (TMPRSS6))
    Autre désignation
    Matriptase 2 (TMPRSS6 Produits)
    Synonymes
    anticorps IRIDA, anticorps 1300008A22Rik, anticorps transmembrane protease, serine 6, anticorps transmembrane serine protease 6, anticorps Tmprss6, anticorps TMPRSS6
    Sujet

    Synonyms: Matriptase-2, Matriptase2, Membrane type serine proteinase 2, MTSP 2, MTSP2, PVAE354, TMPRSS 6, TMPRSS6, TMPS6_HUMAN, TMSP 6, TMSP6, Transmembrane protease serine 6, Type II Membrane Serine Proteinase 6.

    Background: Serine protease which hydrolyzes a range of proteins including type I collagen, fibronectin and fibrinogen. Can also activate urokinase-type plasminogen activator with low efficiency. May play a specialized role in matrix remodeling processes in liver. Required to sense iron deficiency. Overexpression suppresses activation of the HAMP promoter.Involvement in disease:Defects in TMPRSS6 are the cause of iron-refractory iron deficiency anemia (IRIDA), also known as hypochromic microcytic anemia with defect in iron metabolism or hereditary iron-handling disorder or pseudo-iron-deficiency anemia. Key features include congenital hypochromic microcytic anemia, very low mean corpuscular erythrocyte volume, low transferrin saturation, abnormal iron absorption characterized by no hematologic improvement following treatment with oral iron, and abnormal iron utilization characterized by a sluggish, incomplete response to parenteral iron.

    ID gène
    164656
    Pathways
    Transition Metal Ion Homeostasis
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