INIP anticorps (AA 1-50) (HRP)

N° du produit ABIN1420900

Détail du produit anti-INIP anticorps (HRP)

Antigène: INIP (INTS3 and NABP Interacting Protein (INIP))

Épitope: AA 1-50

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp INIP est conjugé à/à la HRP

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Réactivité croisée: Humain, Souris, Rat

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic peptide derived from human SOSSC/C9orf80

Isotype: IgG

Information d'application

Indications d'application: WB 1:300-5000
IHC-P 1:200-400

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Conseil sur la manipulation: Do NOT add Sodium Azide! Use of Sodium Azide will inhibit enzyme activity of horseradish peroxidase.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Date de péremption: 12 months

Détails sur INIP

Antigène: INIP (INTS3 and NABP Interacting Protein (INIP))

Autre désignation: SOSSC (INIP Produits)

Synonymes: anticorps C8H9orf80, anticorps C9orf80, anticorps SSBIP1, anticorps INIP, anticorps HSPC043, anticorps MISE, anticorps SOSSC, anticorps hSSBIP1, anticorps 1110054O05Rik, anticorps 2610312O17Rik, anticorps AA399876, anticorps Ssbip1, anticorps SOSS-C, anticorps ssbip1, anticorps zgc:56259, anticorps zgc:86662, anticorps c9orf80, anticorps hspc043-a, anticorps mise, anticorps sossc, anticorps ci080, anticorps INTS3 and NABP interacting protein, anticorps ints3 and nabp interacting protein, anticorps INTS3 and NABP interacting protein S homeolog, anticorps INIP, anticorps Inip, anticorps inip, anticorps inip.S

Sujet:

Synonyms: INIP, Chromosome 9 open reading frame 80, hSSBIP1, MISE, RP11-276E15.2, Sensor of single-strand DNA complex subunit C, Sensor of ssDNA subunit C, Single-stranded DNA-binding protein-interacting protein 1, SOSS C, SOSS complex subunit C, SOSS-C, SOSSC, SOSSC_HUMAN, SSB-interacting protein 1, Ssbip1, C9orf80, INTS3- and NABP-interacting protein

Background: The SOSS (Sensor of single-strand DNA) complex consists of multiple proteins that promote DNA repair and G2/M checkpoint downstream of the MRN (Mre11, Rad50 and Nbs1) complex. The complex is composed of SSBP1, INTS3 and C9orf80. Specifically, the SOSS complex binds to ssDNA at DNA lesions that influences diverse endpoints in the cellular DNA damage response. The complex is required for efficient homologous recombination-dependent repair of double-stranded breaks and ATM-dependent signaling pathways. C9orf80, also known as SOSS complex subunit C and Single-stranded DNA-binding protein-interacting protein 1 (SSBIP1), is a 104 amino acid nuclear protein that is a component of the SOSS complex. Upon DNA damage, C9orf80 along with other components of the SOSS complex migrate to the nucleus. There are two isoforms of C9orf80 that are produced as a result of alternative splicing events.

ID gène: 58493

UniProt: Q9NRY2