C18orf1 anticorps (AA 1-50) (Cy7)
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- Antigène Voir toutes C18orf1 Anticorps
- C18orf1 (Chromosome 18 Open Reading Frame 1 (C18orf1))
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Épitope
- AA 1-50
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Reactivité
- Humain, Souris, Rat
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp C18orf1 est conjugé à/à la Cy7
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Application
- Western Blotting (WB), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
- Réactivité croisée
- Humain, Souris, Rat
- Purification
- Purified by Protein A.
- Immunogène
- KLH conjugated synthetic peptide derived from human C18orf1
- Isotype
- IgG
- Top Product
- Discover our top product C18orf1 Anticorps primaire
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- Indications d'application
- IF(IHC-P) 1:50-200
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1 μg/μL
- Buffer
- Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
- Agent conservateur
- ProClin
- Précaution d'utilisation
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
- Stock
- -20 °C
- Stockage commentaire
- Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
- Date de péremption
- 12 months
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- Antigène
- C18orf1 (Chromosome 18 Open Reading Frame 1 (C18orf1))
- Autre désignation
- C18orf1 (C18orf1 Produits)
- Synonymes
- anticorps C18orf1, anticorps 8230401C20Rik, anticorps A430083H02, anticorps A430108L08Rik, anticorps D18Ertd653e, anticorps D330030L18Rik, anticorps low density lipoprotein receptor class A domain containing 4, anticorps LDLRAD4, anticorps Ldlrad4
- Sujet
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Synonyms: C18orf1, Low-density lipoprotein receptor class A domain-containing protein 4, LDLRAD4
Background: Functions as a negative regulator of TGF-beta signaling and thereby probably plays a role in cell proliferation, differentiation, apoptosis, motility, extracellular matrix production and immunosuppression. In the canonical TGF-beta pathway, ZFYVE9/SARA recruits the intracellular signal transducer and transcriptional modulators SMAD2 and SMAD3 to the TGF-beta receptor. Phosphorylated by the receptor, SMAD2 and SMAD3 then form a heteromeric complex with SMAD4 that translocates to the nucleus to regulate transcription. Through interaction with SMAD2 and SMAD3, LDLRAD4 may compete with ZFYVE9 and SMAD4 and prevent propagation of the intracellular signal.
- ID gène
- 753
- UniProt
- O15165
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