ZWILCH anticorps (Cy5)

N° du produit ABIN1422210

Détail du produit anti-ZWILCH anticorps (Cy5)

Antigène: ZWILCH (Zwilch, Kinetochore Associated, Homolog (ZWILCH))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp ZWILCH est conjugé à/à la Cy5

Application: Western Blotting (WB), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Réactivité croisée: Humain, Souris, Rat

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic peptide derived from human ZWILCH

Isotype: IgG

Information d'application

Indications d'application: IF(IHC-P) 1:50-200

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Date de péremption: 12 months

Détails sur ZWILCH

Antigène: ZWILCH (Zwilch, Kinetochore Associated, Homolog (ZWILCH))

Autre désignation: ZWILCH (ZWILCH Produits)

Synonymes: anticorps CG18639, anticorps CG18729, anticorps Dmel\\CG18729, anticorps Zwilch, anticorps hzwilch, anticorps kntc1ap, anticorps KNTC1AP, anticorps hZwilch, anticorps 2310031L18Rik, anticorps si:ch211-242m18.4, anticorps wu:fb10f09, anticorps zwilch kinetochore protein, anticorps CG18729 gene product from transcript CG18729-RA, anticorps protein zwilch homolog, anticorps Zwilch, anticorps zwilch, anticorps LOC100374963, anticorps ZWILCH

Sujet:

Synonyms: hZwilch, KNTC1AP, MGC111034, Protein zwilch homolog, ZWILC_HUMAN, zwilch,y ZWILCH protein, Zwilch, kinetochore associated, homolog.

Background: Zwilch is the human homolog of the Drosophila Zwilch protein. The Drosophila Zwilch forms a complex with both ROD Rough Deal) and ZWINT (Zeste-White 10, also designated ZW10) proteins. This complex is important for chromosome segregation because it recruits cytoplasmic Dynein to the kinetochore and plays a crucial role in the spindle checkpoint. The role of Zwilch in complex is thought to be evolutionarily conserved because the human homologs of Zwilch, ZWINT and ROD coimmunoprecipitate in a human cell line called HeLa. The human Zwilch, ZWINT and ROD complex localizes to the kinetochores at prometaphase. Mutations were discovered in Zwilch, ZWINT and ROD during a screen for mutations in alleles encoding putative chromosome instability genes in cases of human colorectal cancer. These mutations may contribute in part to the chromosomal instability phenotype of colorectal tumor cells.

ID gène: 55055

UniProt: Q9H900