Connexin 43/GJA1 anticorps (C-Term)

N° du produit ABIN1440034

Cet anticorps Chèvre Polyclonal détecte spécifiquement Connexin 43/GJA1 dans WB, IF, IHC (p) et IHC (fro). Il présente une réactivité avec des échantillons de Humain, Souris, Rat, Chien, Singe, Boeuf (Vache), Lapin, Poulet, Porc, Cobaye, Cheval, Mouton, Hamster, Chévre, Avian, Cat et Âne. Il a été cité dans 3+ publications.

Aperçu rapide pour Connexin 43/GJA1 anticorps (C-Term) (ABIN1440034)

Antigène: Connexin 43/GJA1 (GJA1) (Gap Junction Protein, alpha 1, 43kDa (GJA1))

Reactivité: Humain, Souris, Rat, Chien, Singe, Boeuf (Vache), Lapin, Poulet, Porc, Cobaye, Cheval, Mouton, Hamster, Chévre, Avian, Cat, Âne

Hôte: Chèvre

Clonalité: Polyclonal

Conjugué: Cet anticorp Connexin 43/GJA1 est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Détail du produit anti-Connexin 43/GJA1 anticorps

Épitope: C-Term

Fonction: Anti-CX43

Séquence: VKDRVKGRSD PYHATTGPLS PSKDCGSPKY AYFNGCSSPT APLSPMSPPG YKLVTGDRNN SSCRNYNKQA SEQNWANYSA EQNRMGQAGS TISNSHAQPF DFPDDNQNAK KVAAGHELQP LAIVDQRPSS RASSRASSRP RPDDLEI

Specificité: Detects endogenous levels of total connexin 43.

Attributs du produit: Gap junction protein, alpha 1, 43 kDa

Purification: Epitope affinity purified

Immunogène: Purified recombinant peptide derived from within residues 230 aa to the C-terminus of rat CX43 produced in E. coli.

Isotype: IgG

Information d'application

Indications d'application: WB:1:500-1:2,000, IF:1:50-1:250, IHC-P:1:250-1:800, IHC-F:1:250-1:800

Restrictions: For Research Use only

Stockage

Concentration: 4 mg/mL

Buffer: PBS, 20 % glycerol and 0.05 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: The antibody solution should be gently mixed before use.

Stock: 4 °C,-20 °C

Stockage commentaire: For continuous use, store at 2-8 C for one-two days. For extended storage, store in -20 C freezer. Working dilution samples should be discarded if not used within 12 hours.

Références pour anticorps anti-Connexin 43/GJA1 (ABIN1440034)

Martins-Marques, Pinho, Zuzarte, Oliveira, Pereira, Sluijter, Gomes, Girao: "Presence of Cx43 in extracellular vesicles reduces the cardiotoxicity of the anti-tumour therapeutic approach with doxorubicin." dans: Journal of extracellular vesicles, Vol. 5, pp. 32538, (2016) (PubMed).

Martins-Marques, Anjo, Pereira, Manadas, Girão: "Interacting Network of the Gap Junction (GJ) Protein Connexin43 (Cx43) is Modulated by Ischemia and Reperfusion in the Heart." dans: Molecular & cellular proteomics : MCP, Vol. 14, Issue 11, pp. 3040-55, (2016) (PubMed).

Ribeiro-Rodrigues, Catarino, Marques, Ferreira, Martins-Marques, Pereira, Girão: "AMSH-mediated deubiquitination of Cx43 regulates internalization and degradation of gap junctions." dans: FASEB journal : official publication of the Federation of American Societies for Experimental Biology, Vol. 28, Issue 11, pp. 4629-41, (2015) (PubMed).

Détails sur Connexin 43/GJA1

Antigène: Connexin 43/GJA1 (GJA1) (Gap Junction Protein, alpha 1, 43kDa (GJA1))

Autre désignation: CX43

Sujet:

Goat polyclonal to connexin 43, which is a member of the connexin family. Cx43 is a component of gap junctions, which are composed of arrays of intercellular channels that provide a route for the diffusion of low molecular weight materials from cell to cell. This protein is the major protein of gap junctions in embryonic development and in the heart that are thought to have a crucial role in the synchronized contraction of the heart.

AVSD3, CX43, DFNB38, gap junction protein, alpha 1, 43 kDa, GJA1, GJAL HSS, HLHS1, ODDD antibody.

Pathways: Signalisation MAPK, Myometrial Relaxation and Contraction, Cell-Cell Junction Organization