NUMA1 anticorps

N° du produit ABIN1449239

Détail du produit anti-NUMA1 anticorps

Antigène: NUMA1 (Nuclear Mitotic Apparatus Protein 1 (NUMA1))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp NUMA1 est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (IF), Immunoprecipitation (IP)

Specificité: This antibody reacts with human NuMA.

Purification: Protein A agarose

Immunogène: Protein fraction extracted from the mitotic chromosome

Clone: C02142

Isotype: IgG1

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Concentration: 1.0 mg/mL

Buffer: PBS containing 50 % glycerol, pH 7.2. No preservative is contained.

Agent conservateur: Without preservative

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: -20 °C

Stockage commentaire: Upon receipt, store (in aliqouts) at -20 °C.

Détails sur NUMA1

Antigène: NUMA1 (Nuclear Mitotic Apparatus Protein 1 (NUMA1))

Autre désignation: NuMA (NUMA1 Produits)

Synonymes: anticorps NUMA, anticorps 6720401E04Rik, anticorps AA764025, anticorps AL022610, anticorps AU014979, anticorps NUMA1, anticorps NuMA, anticorps SP-H, anticorps numa, anticorps numa1, anticorps nuclear mitotic apparatus protein 1, anticorps nuclear mitotic apparatus protein 1 S homeolog, anticorps NUMA1, anticorps Numa1, anticorps numa1, anticorps numa1.S

Sujet: NuMA (Nuclear Mitotic Apparatus Protein) is involved in maintenance of nuclear structure and in the assembly of the mitotic spindle. During interphase, NuMA is present throughout the nucleus, and during mitosis, it localizes to the spindle. It associates with microtubule motors during mitosis, and plays an essential role in anchoring microtubule ends to the spindle poles. NuMA is an autoantigen, and some individuals with connective tissue disease or other autoimmune disorders have antibodies directed against the NuMA protein. Recent data suggests NuMA (240 kDa) is cleaved to a 180-200 kDa form during apoptosis.Synonyms: NUMA1, Nuclear mitotic apparatus protein 1, SP-H antigen

Poids moléculaire: 240 kDa

ID gène: 4926

NCBI Accession: NP_006176

UniProt: Q14980

Pathways: Caspase Cascade in Apoptosis, Regulation of Actin Filament Polymerization, M Phase