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MDM4-binding Protein anticorps (pSer367)
MDM4
Reactivité: Humain, Souris
WB
Hôte: Souris
Monoclonal
#15
unconjugated
N° du produit ABIN1449256
Détail du produit anti-MDM4-binding Protein anticorps
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Antigène
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MDM4-binding Protein (MDM4)
(Mdm4-binding Protein (MDM4))
Épitope
Tous les épitopes à travers MDM4-binding Protein Anticorps.
pSer367
Reactivité
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Humain, Souris
Hôte
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Souris
Clonalité
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Monoclonal
Conjugué
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Cet anticorp MDM4-binding Protein est non-conjugé
Application
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Western Blotting (WB)
Specificité
This antibody specifically recognizes MdmX protein phosphorylated at Ser367.
Réactivité croisée (Details)
Species reactivity (tested):Human, Mouse
Clone
#15
Isotype
IgG2b
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Information d'application
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Indications d'application
Optimal working dilution should be determined by the investigator.
Restrictions
For Research Use only
Stockage
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Concentration
1.0 mg/mL
Buffer
PBS containing 50 % glycerol, pH 7.2. No preservative is contained.
Agent conservateur
Without preservative
Conseil sur la manipulation
Avoid repeated freezing and thawing.
Stock
-20 °C
Stockage commentaire
Upon receipt, store (in aliqouts) at -20 °C.
Détails sur MDM4-binding Protein
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Antigène
MDM4-binding Protein (MDM4)
(Mdm4-binding Protein (MDM4))
Autre désignation
MDM4 (MDM4 Produits )
Synonymes
anticorps mdmx, anticorps HDMX, anticorps MDMX, anticorps MRP1, anticorps wu:fa09h09, anticorps wu:fi33d10, anticorps 4933417N07Rik, anticorps AA414968, anticorps AL023055, anticorps AU018793, anticorps AU021806, anticorps C85810, anticorps Mdmx, anticorps MDM4, p53 regulator S homeolog, anticorps MDM4, p53 regulator, anticorps transformed mouse 3T3 cell double minute 4, anticorps mdm4.S, anticorps MDM4, anticorps Mdm4, anticorps mdm4
Sujet
MdmX (Mdm4, HdmX) inhibits p53-and p73-dependent cell cycle arrest and apoptosis by binding to the transcription activation domains of these proteins. MdmX consists of 490 amino acids with the molecular weight of 54,864 and contains a RIING-finger domain and a nuclear transport signal. It is known that the protein migrates aberrantly in SDS-PAGE at the position of an 80 kDa protein. MdmX is phosphorylated at Ser367 by Chk2 kinase downstream of ATM in response to DNA damage, and as the result, it binds to 14-3-3 and is transported into nucleus where it is degraded by Mdm2. This process activates the p53 functions (Ref 1, 2, 3).Synonyms: Double minute 4 protein, MDM-4, MDMX, Mdm2-like p53-binding protein, p53-binding protein Mdm4
ID gène
4194
NCBI Accession
NP_002384
UniProt
O15151
Pathways
Cycle Cellulaire
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