ICAM1 anticorps (FITC)
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- Antigène Voir toutes ICAM1 Anticorps
- ICAM1 (Intercellular Adhesion Molecule 1 (ICAM1))
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Reactivité
- Humain
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Hôte
- Souris
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Clonalité
- Monoclonal
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Conjugué
- Cet anticorp ICAM1 est conjugé à/à la FITC
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Application
- Flow Cytometry (FACS)
- Purification
- Protein A agarose
- Immunogène
- Human myeloma cell line (RPMI8226)
- Clone
- WK1
- Isotype
- IgG1
- Top Product
- Discover our top product ICAM1 Anticorps primaire
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- Indications d'application
- Optimal working dilution should be determined by the investigator.
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 0.5 mg/mL
- Buffer
- PBS containing 1 % BSA and 0.09 % NaN3.
- Stock
- 4 °C
- Stockage commentaire
- Store at 2-8 °C.
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- Antigène
- ICAM1 (Intercellular Adhesion Molecule 1 (ICAM1))
- Autre désignation
- CD54 / ICAM1 (ICAM1 Produits)
- Synonymes
- anticorps BB2, anticorps CD54, anticorps P3.58, anticorps Icam-1, anticorps Ly-47, anticorps MALA-2, anticorps ICAM, anticorps ICAM-1, anticorps ICAM1, anticorps intercellular adhesion molecule 1, anticorps intercellular adhesion molecule-1, anticorps ICAM1, anticorps Icam1, anticorps ICAM-1
- Classe de substances
- Viral Protein
- Sujet
- Intercellular adhesion molecules (ICAMs) are type I transmem brane glycoproteins, which contain 2-9 immunoglobulin-like C2-type domains, and bind to lymphocyte function- associated antigen-1 (LFA-1, also known as a L/ ß 2 or CD11a/CD18). ICAM-1 (CD54) binds to not only LFA-1 but also CD11b/CD18 (Mac-1) and CD11c/CD18. ICAM-1 is also the major receptor for human rhinovirus. ICAM-1 and LFA-1 are involved in the formation of the adhesion ring junction at the immunologic synapse between T cells and antigen presenting cells. ICAM-1 is expressed at low levels on diverse cell types, and is readily induced by activation with proinflammatory cytokines such as IL-1, TNF, IFN- γ , and GM-CSF. ICAM-1 plays a role in both adhesion and extravasation of leukocytes to endothelium during inflammation. Soluble forms of ICAM-1 (sICAM-1) have been detected in a variety of body fluids and correlated with the intensity of the clinical condition of inflammatory and immune disorders. Several studies have provided evidence that sICAM-1 can bind to cell surface ß 2 integrins (CD18), causing reduced adherence of leukocytes to endothelial cells and the accompanying intracellular signaling responses.Synonyms: ICAM-1, Intercellular adhesion molecule 1, Major Group Rhinovirus Receptor
- ID gène
- 9606
- UniProt
- P05362
- Pathways
- Cellular Response to Molecule of Bacterial Origin, Regulation of Actin Filament Polymerization, Carbohydrate Homeostasis, Regulation of Leukocyte Mediated Immunity, Thromboxane A2 Receptor Signaling
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