CD5 anticorps (FITC)
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- Antigène Voir toutes CD5 Anticorps
- CD5
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Reactivité
- Humain
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Hôte
- Souris
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Clonalité
- Monoclonal
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Conjugué
- Cet anticorp CD5 est conjugé à/à la FITC
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Application
- Flow Cytometry (FACS)
- Réactivité croisée (Details)
- Species reactivity (tested):Human
- Immunogène
- Human acute lymphoblastic leukemia (ALL) T cells
- Clone
- L17F12
- Isotype
- IgG2a
- Top Product
- Discover our top product CD5 Anticorps primaire
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- Indications d'application
- Optimal working dilution should be determined by the investigator.
- Restrictions
- For Research Use only
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- Buffer
- PBS, 15 mM sodium azide, 0.2 % (w/v) high-grade protease free Bovine Serum Albumin
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Conseil sur la manipulation
- DO NOT FREEZE! This products is photosensitive and should be protected from light.
- Stock
- 4 °C
- Stockage commentaire
- Store undiluted at 2-8 °C.
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- Antigène
- CD5
- Autre désignation
- CD5 (CD5 Produits)
- Synonymes
- anticorps CD5, anticorps Ly-1, anticorps Ly-12, anticorps Ly-A, anticorps Lyt-1, anticorps LEU1, anticorps T1, anticorps CD5 molecule, anticorps CD5 antigen, anticorps CD5 molecule like, anticorps Cd5 molecule, anticorps CD5, anticorps Cd5, anticorps CD5L
- Sujet
- CD5 antigen (T1, 67 kDa) is a human cell surface T-lymphocyte single-chain transmembrane glycoprotein. CD5 is expressed on all mature T-lymphocytes, most of thymocytes, subset of B-lymphocytes and on many T-cell leukemias and lymphomas. It is a type I membrane glycoprotein whose extracellular region contains three scavenger receptor cysteine-rich (SRCR) domains. The CD5 is a signal transducing molecule whose cytoplasmic tail is devoid of any intrinsic catalytic activity. CD5 modulates signaling through the antigen-specific receptor complex (TCR and BCR). CD5 crosslinking induces extracellular Ca++ mobilization, tyrosine phosphorylation of intracellular proteins and DAG production. Preliminary evidence shows protein associations with ZAP-70, p56lck, p59fyn, PC-PLC, etc. CD5 may serve as a dual receptor, giving either stimulatory or inhibitory signals depending both on the cell type and development stage. In thymocytes and B1a cells seems to provide inhibitory signals, in peripheral mature T lymhocytes it acts as a costimulatory signal receptor. CD5 is the phenotypic marker of a B cell subpopulation involved in the production of autoreactive antibodies. Disease relevance: CD5 is a phenotypic marker for some B cell lymphoproliferative disorders (B-CLL, Hairy cell leukemia, etc.). The CD5+ popuation is expanded in some autoimmune disorders (Rheumatoid Arthritis, etc.). Herpes virus infections induce loss of CD5 expression in the expanded CD8+ human T cells.Synonyms: CD5, LEU1, Lymphocyte antigen T1/Leu-1, T-cell surface glycoprotein CD5
- UniProt
- P06127
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