PIK3C3 anticorps (AA 19-49)

N° du produit ABIN1449618

Détail du produit anti-PIK3C3 anticorps

Antigène: PIK3C3 (Phosphoinositide-3-Kinase, Class 3 (PIK3C3))

Épitope: AA 19-49

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp PIK3C3 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Purification: Protein A column, followed by peptide affinity purification.

Immunogène: KLH conjugated synthetic peptide between 19~49 amino acids surrounding Serine 34 of Human PI3KC3

Isotype: Ig Fraction

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.25 mg/mL

Buffer: PBS containing 0.09 % (W/V) Sodium Azide as preservative

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Références pour anticorps anti-PIK3C3 (ABIN1449618)

Lacroix Pépin, Chapdelaine, Rodriguez, Tremblay, Fortier: "Generation of human endometrial knockout cell lines with the CRISPR/Cas9 system confirms the prostaglandin F2α synthase activity of aldo-ketoreductase 1B1." dans: Molecular human reproduction, Vol. 20, Issue 7, pp. 650-63, (2015) (PubMed).

Eleftheriadis, Pissas, Antoniadi, Liakopoulos, Stefanidis: "Indoleamine 2,3-dioxygenase depletes tryptophan, activates general control non-derepressible 2 kinase and down-regulates key enzymes involved in fatty acid synthesis in primary human CD4+ T cells." dans: Immunology, Vol. 146, Issue 2, pp. 292-300, (2015) (PubMed).

Guess, Ayoob, Chanley, Manley, Cajaiba, Agrawal, Pengal, Pyle, Becknell, Kopp, Ronkina, Gaestel, Benndorf, Smoyer: "Crucial roles of the protein kinases MK2 and MK3 in a mouse model of glomerulonephritis." dans: PLoS ONE, Vol. 8, Issue 1, pp. e54239, (2013) (PubMed).

Minakami, Maehara, Kamakura, Kumano, Miyano, Sumimoto: "Membrane phospholipid metabolism during phagocytosis in human neutrophils." dans: Genes to cells : devoted to molecular & cellular mechanisms, Vol. 15, Issue 5, pp. 409-24, (2010) (PubMed).

May, Sureban, Lightfoot, Hoskins, Brackett, Postier, Ramanujam, Rao, Wyche, Anant, Houchen: "Identification of a novel putative pancreatic stem/progenitor cell marker DCAMKL-1 in normal mouse pancreas." dans: American journal of physiology. Gastrointestinal and liver physiology, Vol. 299, Issue 2, pp. G303-10, (2010) (PubMed).

Détails sur PIK3C3

Antigène: PIK3C3 (Phosphoinositide-3-Kinase, Class 3 (PIK3C3))

Autre désignation: PIK3C3 (PIK3C3 Produits)

Synonymes: anticorps im:7147158, anticorps wu:fc13g06, anticorps wu:fz51e12, anticorps zgc:112016, anticorps zgc:113009, anticorps VPS34, anticorps hVps34, anticorps 5330434F23Rik, anticorps Vps34, anticorps phosphatidylinositol 3-kinase catalytic subunit type 3, anticorps phosphatidylinositol 3-kinase catalytic subunit type 3 L homeolog, anticorps phosphatidylinositol 3-kinase, catalytic subunit type 3, anticorps PIK3C3, anticorps pik3c3.L, anticorps pik3c3, anticorps Pik3c3

Sujet: PI3KC3 is a catalytic subunit of the PI3K complex involved in the transport of lysosomal enzyme precursors to lysosomes. This enzyme acts catalytically to convert 1-phosphatidyl-1D-myo-inositol to 1-phosphatidyl-1D-myo-inositol 3-phosphate. Macroautophagy is the major inducible pathway for the general turnover of cytoplasmic constituents in eukaryotic cells, it is also responsible for the degradation of active cytoplasmic enzymes and organelles during nutrient starvation. Macroautophagy involves the formation of double-membrane bound autophagosomes which enclose the cytoplasmic constituent targeted for degradation in a membrane bound structure, which then fuse with the lysosome (or vacuole) releasing a single-membrane bound autophagic bodies which are then degraded within the lysosome (or vacuole). The regulation of the Beclin 1-PI3KC3 complex lipid kinase activity is a critical element in the autophagy signaling pathway.Synonyms: PI3-kinase type 3, PI3K type 3, Phosphatidylinositol 3-kinase catalytic subunit type 3, Phosphoinositide-3-kinase class 3, VPS34

Poids moléculaire: 101549 Da

ID gène: 5289

NCBI Accession: NP_002638

Pathways: AMPK Signaling, Activation of Innate immune Response, Inositol Metabolic Process, Toll-Like Receptors Cascades, Autophagy