ALG8 anticorps

N° du produit ABIN1449889

Détail du produit anti-ALG8 anticorps

Antigène: ALG8 (Asparagine-Linked Glycosylation 8, alpha-1,3-Glucosyltransferase Homolog (ALG8))

Reactivité: Humain, Souris, Boeuf (Vache), Chien, Porc, Rat, Poulet

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp ALG8 est non-conjugé

Application: Western Blotting (WB)

Séquence: LELKLLDPSQ IPRASMTSGL VQQSQHTVLP SVSPSATLIC TLIAILPSVF

Réactivité croisée (Details): Species reactivity (expected):Mouse, Human, Chicken, Dog, Bovine, PigSpecies reactivity (tested):Human

Purification: Purified using peptide immunoaffinity column

Immunogène: Synthetic peptide corresponding to a region of Rat ALG8

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Reconstitution: Add 50 μL of distilled water to a final concentration of 1 mg/mL.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Store lyophilized at 2-8 °C or at -20 °C long term. After reconstitution store the antibody undiluted at 2-8 °C for up to one month or in aliquots at -20 °C long term.

Détails sur ALG8

Antigène: ALG8 (Asparagine-Linked Glycosylation 8, alpha-1,3-Glucosyltransferase Homolog (ALG8))

Autre désignation: ALG8 (ALG8 Produits)

Synonymes: anticorps CDG1H, anticorps AI447372, anticorps Gm1089, anticorps ALG8, alpha-1,3-glucosyltransferase, anticorps asparagine-linked glycosylation 8 (alpha-1,3-glucosyltransferase), anticorps ALG8, anticorps Alg8

Sujet: ALG8 adds the second glucose residue to the lipid-linked oligosaccharide precursor for N-linked glycosylation and transfers glucose from dolichyl phosphate glucose (Dol-P-Glc) onto the lipid-linked oligosaccharide Glc1Man9GlcNAc(2)-PP-Dol. Defects in ALG8 are the cause of congenital disorder of glycosylation type 1H (CDG1H). CDGs are a family of severe inherited diseases caused by a defect in protein N-glycosylation. They are characterized by under-glycosylated serum proteins. These multisystem disorders present with a wide variety of clinical features, such as disorders of the nervous system development, psychomotor retardation, dysmorphic features, hypotonia, coagulation disorders, and immunodeficiency. The broad spectrum of features reflects the critical role of N-glycoproteins during embryonic development, differentiation, and maintenance of cell functions.Synonyms: 3-glucosyltransferase, Asparagine-linked glycosylation protein 8, Dolichyl-P-Glc:Glc1Man9GlcNAc2-PP-dolichyl glucosyltransferase, HUSSY-02, Probable dolichyl pyrophosphate Glc1Man9GlcNAc2 alpha-1

ID gène: 293129

NCBI Accession: NP_001029299

Pathways: SARS-CoV-2 Protein Interactome