PHLPP2 anticorps (C-Term)

N° du produit ABIN1449986

Détail du produit anti-PHLPP2 anticorps

Antigène: PHLPP2 (PH Domain and Leucine Rich Repeat Protein Phosphatase 2 (PHLPP2))

Épitope: C-Term

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp PHLPP2 est non-conjugé

Application: Western Blotting (WB), Enzyme Immunoassay (EIA)

Purification: Affinity chromatography purified via peptide column

Immunogène: PHLPP2 antibody was raised against a 20 amino acid synthetic peptide near the carboxy terminus of human PHLPP2.

Isotype: IgG

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Concentration: 1.0 mg/mL

Buffer: PBS containing 0.02 % Sodium Azide as preservative

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: -20 °C

Stockage commentaire: Store the antibody (in aliquots) at -20 °C.

Détails sur PHLPP2

Antigène: PHLPP2 (PH Domain and Leucine Rich Repeat Protein Phosphatase 2 (PHLPP2))

Autre désignation: PHLPP2 (PHLPP2 Produits)

Synonymes: anticorps PHLPPL, anticorps phlppl, anticorps AI481772, anticorps C130044A18Rik, anticorps Phlppl, anticorps RGD1562857, anticorps PH domain and leucine rich repeat protein phosphatase 2, anticorps PH domain and leucine rich repeat protein phosphatase 2 S homeolog, anticorps PHLPP2, anticorps phlpp2.S, anticorps phlpp2, anticorps Phlpp2

Sujet: PHLPP2 is a member of the serine/threonine phosphatase family, which are important regulators of Akt serine-threonine kinases (AKT1, AKT2, AKT3) and conventional/novel protein kinase C (PKC) isoforms. PHLPP1 and PHLPP2 have a similar domain structure and have been shown to dephosphorylate and inactivate, distinct Akt isoforms, at one of the two critical phosphorylation sites required for activation: Serine473. PHLPP2 dephosphorylates AKT1 and AKT3, whereas PHLPP1 is specific for AKT2 and AKT3. PHLPP1 promotes apoptosis and may act as a tumor suppressor. PHLPP2 associates with and is inhibited by adenylyl cyclase type 6 (AC6), thereby allowing Akt activation .Synonyms: KIAA0931, PH domain leucine-rich repeat-containing protein phosphatase 2, PH domain leucine-rich repeat-containing protein phosphatase-like, PHLPP-like, PHLPPL

Poids moléculaire: 156 kDa

ID gène: 23035

NCBI Accession: NP_055835

Pathways: Signalisation PI3K-Akt, Fc-epsilon Receptor Signaling Pathway