GFRA2 anticorps

N° du produit ABIN1450225

Détail du produit anti-GFRA2 anticorps

Antigène: GFRA2 (GDNF Family Receptor alpha 2 (GFRA2))

Reactivité: Humain

Hôte: Poulet

Clonalité: Polyclonal

Conjugué: Cet anticorp GFRA2 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF)

Specificité: Glial cell line-derived neurotrophic factor (GDNF) andneurturin (NTN) are two structurally related, potent neurotrophic factors thatplay key roles in the control of neuron survival and differentiation. GFRa-2 isa member of the GDNF receptor family. It is a glycosylphosphatidyl-inositol(GPI)-linkedcell surface receptor for both GDNF and NTN, and mediates activation of the RETtyrosine kinase receptor. This encoded protein acts preferentially as areceptor for NRTN compared to its other family member, GDNF family receptoralpha 1. http://www.ncbi.nlm.nih.gov/gene/2675

Attributs du produit: Mono- and polyclonal antibodies to human growth factors and neural growth factor receptors.

Purification: GFRa-2 affinity purified

Isotype: IgY

Information d'application

Indications d'application: Western immunoblotting, recommended dilution 1:5 000to 1:10 000, ELISA: 1:128 000 to 160 000, IF 1:500 to1:1000. Polyclonal antibody working titer has to beestablished practically for each particular antigen and assay format

Commentaires:

Synonym: GDNF receptor beta, Neurturin receptor alpha, RETligand 2TGF-beta-related neurotrophic factor receptor 2

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/ml

Buffer: Concentrated ammonium sulphate in PBS pH 7.4

Conseil sur la manipulation: As product is (NH4)2SO4 precipitate, mix well by pipetting or vortexing prior use

Stock: 4 °C

Stockage commentaire: This product is shipped in non-frozen liquid form in ambient conditions

Références pour anticorps anti-GFRA2 (ABIN1450225)

Siatra, Vatsellas, Chatzianastasiou, Balafas, Manolakou, Papapetropoulos, Agapaki, Mouchtouri, Ruchaya, Korovesi, Mavroidis, Thanos, Beis, Kokkinopoulos: "Return of the Tbx5; lineage-tracing reveals ventricular cardiomyocyte-like precursors in the injured adult mammalian heart." dans: NPJ Regenerative medicine, Vol. 8, Issue 1, pp. 13, (2023) (PubMed).

Détails sur GFRA2

Antigène: GFRA2 (GDNF Family Receptor alpha 2 (GFRA2))

Autre désignation: GFRa-2 (GFRA2 Produits)

Synonymes: anticorps GDNFRB, anticorps NRTNR-ALPHA, anticorps NTNRA, anticorps RETL2, anticorps TRNR2, anticorps Retl2, anticorps NTNRALPHA, anticorps ntnra, anticorps retl2, anticorps trnr2, anticorps gdnfrb, anticorps nrtnr-alpha, anticorps gfra2, anticorps GDNF family receptor alpha 2, anticorps glial cell line derived neurotrophic factor family receptor alpha 2, anticorps GDNF family receptor alpha 2a, anticorps GFRA2, anticorps Gfra2, anticorps gfra2, anticorps gfra2a

Sujet: Recombinant His-tagged human GFRα-2 protein producedusing CHO-based cell line. For production of hGFRα-2, glycosylphosphatidyl-inositol GPI-anchor was removedand protein was secreted to the cell culture supernatant. Protein was purifiedby Ni-affinity chromatography following gel-filtration from cell culturesupernatant

UniProt: O00451