Akirin 1 anticorps (C-Term)

N° du produit ABIN1536697

Détail du produit anti-Akirin 1 anticorps

Antigène: Akirin 1 (AKIRIN1)

Épitope: AA 131-158, C-Term

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Akirin 1 est non-conjugé

Application: Western Blotting (WB)

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogène: This AKIR1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 131-158 amino acids from the C-terminal region of human AKIR1.

Clone: RB25247

Isotype: Ig Fraction

Information d'application

Indications d'application: WB: 1:1000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: AKIR1 Antibody (C-term) can be refrigerated at 2-8 °C for up to 6 months. For long term storage, keep at -20 °C.

Date de péremption: 6 months

Détails sur Akirin 1

Antigène: Akirin 1 (AKIRIN1)

Autre désignation: AKIR1 (AKIRIN1 Produits)

Synonymes: anticorps C1orf108, anticorps RP11-781D11.2, anticorps STRF2, anticorps 6330407G11Rik, anticorps wu:fa96c11, anticorps wu:fc08a11, anticorps zgc:64050, anticorps AKIRIN1, anticorps strf2, anticorps akirin 1, anticorps akirin 1 S homeolog, anticorps akirin-1 pseudogene, anticorps AKIRIN1, anticorps Akirin1, anticorps akirin1, anticorps akirin1.S, anticorps LOC100316864, anticorps LOC100356339

Sujet: The highly conserved, nuclear-localized AKIRIN1 and Akirin2 proteins critically regulate the transcription of NF-kB dependent genes and are required for defense against Gram-negative bacteria in the immune deficiency and NF-kB pathways. AKIRIN1 is dispensable in the mouse, and neither knockout mice nor cells derived from them have obvious distinctive phenotypes. In contrast, Akirin2 is required for development in the mouse and knockout of both Akirin homologs in mice show that Akirin2 is required downstream of toll-like receptor (TLR), TNF-alpha and IL-1beta signaling, and for the production of IL-6. Akirin2 is functionally closer to the single gene in Drosophila, as the homozygous null D. melanogaster Akirin mutants show a similar, mid-to-early embryonic death.

Poids moléculaire: 21867

ID gène: 79647

NCBI Accession: NP_001129747, NP_078871

UniProt: Q9H9L7