Zona Pellucida Glycoprotein 3 anticorps (C-Term)

N° du produit ABIN1537191

Détail du produit anti-Zona Pellucida Glycoprotein 3 anticorps

Antigène: Zona Pellucida Glycoprotein 3 (ZP3)

Épitope: AA 353-380, C-Term

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Zona Pellucida Glycoprotein 3 est non-conjugé

Application: Western Blotting (WB)

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogène: This ZP3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 353-380 amino acids from the C-terminal region of human ZP3.

Clone: RB36988

Isotype: Ig Fraction

Information d'application

Indications d'application: WB: 1:1000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: ZP3 Antibody (C-term) can be refrigerated at 2-8 °C for up to 6 months. For long term storage, keep at -20 °C.

Date de péremption: 6 months

Références pour anticorps anti-Zona Pellucida Glycoprotein 3 (ABIN1537191)

Mask, Schoenecker, Kane, Ransom, Bruemmer: "Serum antibody immunoreactivity to equine zona protein after SpayVac vaccination." dans: Theriogenology, Vol. 84, Issue 2, pp. 261-7, (2015) (PubMed).

Détails sur Zona Pellucida Glycoprotein 3

Antigène: Zona Pellucida Glycoprotein 3 (ZP3)

Autre désignation: ZP3 (ZP3 Produits)

Synonymes: anticorps ZP3A, anticorps ZP3B, anticorps ZPC, anticorps Zp-3, anticorps zp3.2, anticorps Zp-3B, anticorps zona pellucida glycoprotein 3, anticorps zona pellucida sperm-binding protein 3, anticorps ZP3, anticorps zp3, anticorps Zp3

Sujet: The zona pellucida is an extracellular matrix that surrounds the oocyte and early embryo. It is composed primarily of three or four glycoproteins with various functions during fertilization and preimplantation development. The protein encoded by this gene is a structural component of the zona pellucida and functions in primary binding and induction of the sperm acrosome reaction. The nascent protein contains a N-terminal signal peptide sequence, a conserved ZP domain, a C-terminal consensus furin cleavage site, and a transmembrane domain. It is hypothesized that furin cleavage results in release of the mature protein from the plasma membrane for subsequent incorporation into the zona pellucida matrix. However, the requirement for furin cleavage in this process remains controversial based on mouse studies. A variation in the last exon of this gene has previously served as the basis for an additional ZP3 locus, however, sequence and literature review reveals that there is only one full-length ZP3 locus in the human genome. Another locus encoding a bipartite transcript designated POMZP3 contains a duplication of the last four exons of ZP3, including the above described variation, and maps closely to this gene.

Poids moléculaire: 47018

ID gène: 7784

NCBI Accession: NP_001103824, NP_009086

UniProt: P21754

Pathways: Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process