LKB1 anticorps (C-Term)

N° du produit ABIN1537274

Il existe 1 publication pour ce produit. L’anticorps anti-LKB1 Polyclonal Lapin est utilisé pour la détection de LKB1 dans des échantillons de Humain. Il a été validé pour IHC (p).

Aperçu rapide pour LKB1 anticorps (C-Term) (ABIN1537274)

Antigène: LKB1 (STK11) (serine/threonine Kinase 11 (STK11))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp LKB1 est non-conjugé

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: RB3549-3550

Détail du produit anti-LKB1 anticorps

Épitope: AA 387-417, C-Term

Purification: This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Immunogène: This STK11 (LKB1) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 387-417 amino acids from the C-terminal region of human STK11 (LKB1).

Isotype: Ig Fraction

Information d'application

Indications d'application: IHC-P: 1:50~100

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Maintain refrigerated at 2-8 deg C for up to 6 months. For long term storage store at -20 deg C in small aliquots to prevent freeze-thaw cycles.

Date de péremption: 6 months

Références pour anticorps anti-LKB1 (ABIN1537274)

Dahmani, Just, Delay, Canal, Finzi, Prip-Buus, Lambert, Sujobert, Buchet-Poyau, Miller, Cavard, Marmier, Terris, Billaud, Perret: "A novel LKB1 isoform enhances AMPK metabolic activity and displays oncogenic properties." dans: Oncogene, Vol. 34, Issue 18, pp. 2337-46, (2015) (PubMed).

Détails sur LKB1

Antigène: LKB1 (STK11) (serine/threonine Kinase 11 (STK11))

Autre désignation: STK11 (LKB1)

Sujet: STK11, is a member of the serine/threonine kinase family, regulates cell polarity and functions as a tumor suppressor. Mutations in STK11 have been associated with Peutz-Jeghers syndrome, an autosomal dominant disorder characterized by the growth of polyps in the gastrointestinal tract, pigmented macules on the skin and mouth, and other neoplasms.

Poids moléculaire: 48636

ID gène: 6794

NCBI Accession: NP_000446

UniProt: Q15831

Pathways: AMPK Signaling, Carbohydrate Homeostasis, Regulation of Carbohydrate Metabolic Process, L'effet Warburg