RAD50 anticorps (C-Term)

N° du produit ABIN1537647

Détail du produit anti-RAD50 anticorps

Antigène: RAD50 (RAD50 Homolog (S. Cerevisiae) (RAD50))

Épitope: AA 911-938, C-Term

Reactivité: Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp RAD50 est non-conjugé

Application: Western Blotting (WB)

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogène: This Mouse Rad50 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 911-938 amino acids from the C-terminal region of mouse Rad50.

Clone: RB40014

Isotype: Ig Fraction

Information d'application

Indications d'application: WB: 1:1000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Mouse Rad50 Antibody (C-term) can be refrigerated at 2-8 °C for up to 6 months. For long term storage, keep at -20 °C.

Date de péremption: 6 months

Détails sur RAD50

Antigène: RAD50 (RAD50 Homolog (S. Cerevisiae) (RAD50))

Autre désignation: Rad50 (RAD50 Produits)

Synonymes: anticorps NBSLD, anticorps RAD502, anticorps hRad50, anticorps Mrell, anticorps Rad50l, anticorps 6339, anticorps CG6339, anticorps Dmel\\CG6339, anticorps Dmrad50, anticorps RAD50, anticorps Rad50, anticorps ATRAD50, anticorps DNA REPAIR-RECOMBINATION PROTEIN, anticorps F22D22.28, anticorps F22D22_28, anticorps SPAP4C9.01c, anticorps im:6906849, anticorps si:ch211-79h18.3, anticorps RAD50 double strand break repair protein, anticorps CG6339 gene product from transcript CG6339-RE, anticorps RAD50 homolog, double strand break repair protein L homeolog, anticorps rad50, anticorps DNA repair protein RAD50, anticorps RAD50 homolog, double strand break repair protein, anticorps DNA repair-recombination protein (RAD50), anticorps MRX complex DNA-binding subunit, anticorps DNA repair protein Rad50, anticorps RAD50 recombination protein, anticorps Rad50 DNA repair/recombination protein, anticorps DNA repair protein rad-50, anticorps RAD50, anticorps Rad50, anticorps rad50, anticorps rad50.L, anticorps LOC658288, anticorps LOC726642, anticorps rad-50

Sujet: Component of the MRN complex, which plays a central role in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity and meiosis. The complex possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity, which are provided by MRE11A. RAD50 may be required to bind DNA ends and hold them in close proximity. This could facilitate searches for short or long regions of sequence homology in the recombining DNA templates, and may also stimulate the activity of DNA ligases and/or restrict the nuclease activity of MRE11A to prevent nucleolytic degradation past a given point. The complex may also be required for DNA damage signaling via activation of the ATM kinase. In telomeres the MRN complex may modulate t-loop formation (By similarity).

Poids moléculaire: 153488

ID gène: 19360

UniProt: P70388

Pathways: Réparation de l'ADN, Protein targeting to Nucleus