This antibody is purified through a protein A column, followed by peptide affinity purification.
Immunogène
This PPP4R2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 228-254 amino acids from the Central region of human PPP4R2.
anticorps PP4R2, anticorps BE691708, anticorps C230060M08Rik, anticorps ppp4r2, anticorps fe11b04, anticorps wu:fe11b04, anticorps ppp4r2-B, anticorps wu:fa17h08, anticorps wu:fc23g05, anticorps protein phosphatase 4 regulatory subunit 2, anticorps protein phosphatase 4, regulatory subunit 2, anticorps protein phosphatase 4, regulatory subunit 2a, anticorps protein phosphatase 4 regulatory subunit 2 S homeolog, anticorps protein phosphatase 4 regulatory subunit 2 L homeolog, anticorps protein phosphatase 4, regulatory subunit 2b, anticorps PPP4R2, anticorps Ppp4r2, anticorps ppp4r2a, anticorps ppp4r2.S, anticorps ppp4r2, anticorps ppp4r2.L, anticorps ppp4r2b
Sujet
Regulatory subunit of serine/threonine-protein phosphatase 4 (PP4). May regulate the activity of PPP4C at centrosomal microtubule organizing centers. Its interaction with the SMN complex leads to enhance the temporal localization of snRNPs, suggesting a role of PPP4C in maturation of spliceosomal snRNPs. The PPP4C-PPP4R2-PPP4R3A PP4 complex specifically dephosphorylates H2AFX phosphorylated on 'Ser-140' (gamma-H2AFX) generated during DNA replication and required for DNA DSB repair.